Peripheral blood lymphocyte subsets change after steroid withdrawal in renal allograft recipients: a prospective study
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- dc.contributor.author Llinàs-Mallol, Laura
- dc.contributor.author Redondo Pachón, María Dolores
- dc.contributor.author Pérez-Sáez, María José
- dc.contributor.author Raïch-Regué, Dàlia
- dc.contributor.author Mir, Marisa
- dc.contributor.author Yélamos López, José
- dc.contributor.author López-Botet, M. (Miguel)
- dc.contributor.author Pascual Santos, Julio
- dc.contributor.author Crespo Barrio, Marta
- dc.date.accessioned 2019-06-04T07:31:18Z
- dc.date.available 2019-06-04T07:31:18Z
- dc.date.issued 2019
- dc.description.abstract Several studies have assessed clinical outcomes after steroid withdrawal (SW) in kidney transplant (KT) recipients, but little is known about its potential impact on lymphocyte subpopulations. We designed a prospective study to evaluate the long-term impact of SW in 19 KT recipients compared to 16 KT recipients without changes in immunosuppression (steroid maintenance, SM). We assessed renal function, presence of HLA antibodies and peripheral blood lymphocyte subsets at time of inclusion, and 3, 12 and 24 months later. The immunophenotype of 20 healthy subjects was also analyzed. Serum creatinine and proteinuria remained stable in SW and SM patients. SW did not associate with generation of de novo donor-specific antibodies. SW patients showed decreases in T-lymphocytes (p < 0.001), and in the CD4+ T cell subpopulation (p = 0.046). The proportion of B-lymphocytes (p = 0.017), and both naïve and transitional B cells increased compared to SM patients (p < 0.001). Changes in B cell subsets were detected 3 months after SW and persisted for 24 months. No changes were observed in NK cells related to steroid withdrawal. SW patients displayed significant changes in peripheral T and B cell subsets, transitioning to the phenotype detected in healthy subjects. This may be considered as a maintained positive effect of SW previously unnoticed.
- dc.format.mimetype application/pdf
- dc.identifier.citation Llinàs-Mallol L, Redondo-Pachón D, Pérez-Sáez MJ, Raïch-Regué D, Mir M, Yélamos J, López-Botet M, Pascual J, Crespo M. Peripheral blood lymphocyte subsets change after steroid withdrawal in renal allograft recipients: a prospective study. Sci Rep. 2019; 9(1):7453. DOI 10.1038/s41598-019-42913-4
- dc.identifier.doi http://dx.doi.org/10.1038/s41598-019-42913-4
- dc.identifier.issn 2045-2322
- dc.identifier.uri http://hdl.handle.net/10230/41695
- dc.language.iso eng
- dc.publisher Nature Research
- dc.relation.ispartof Sci Rep. 2019; 9(1):7453
- dc.rights © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Medical research
- dc.subject.keyword Nephrology
- dc.title Peripheral blood lymphocyte subsets change after steroid withdrawal in renal allograft recipients: a prospective study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion