Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study
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- dc.contributor.author Morozova, Alexandra
- dc.contributor.author Španiel, Filip
- dc.contributor.author Škoch, Antonín
- dc.contributor.author Brabec, Marek
- dc.contributor.author Zolotarov, Grygoriy
- dc.contributor.author Musil, Vladimir
- dc.contributor.author Zach, Petr
- dc.date.accessioned 2024-12-09T07:18:19Z
- dc.date.available 2024-12-09T07:18:19Z
- dc.date.issued 2024
- dc.description.abstract Enlarged perivascular spaces (EPVS) are increasingly recognized as an MRI detectable feature of neuroinflammatory processes and age-related neurodegenerative changes. Understanding perivascular characteristics in healthy individuals is crucial for their applicability as a reference for pathological changes. Limited data exists on the EPVS load and interhemispheric asymmetry in distribution among young healthy subjects. Despite the known impact of hydration on brain morphometric studies, blood plasma osmolality's effect on EPVS remains unexplored. This study investigated the influence of age, total intracranial volume (TIV), and blood plasma osmolality on EPVS characteristics in 59 healthy adults, each undergoing MRI and osmolality assessment twice within 14.8 months (mean ± 4 months). EPVS analysis was conducted in the centrum semiovale using high-resolution automated segmentation, followed by an optimization algorithm to enhance EPVS segmentation accuracy. Linear Mixed Effects model was used for the statistical analysis, which unveiled significant inter-individual variability in EPVS load and inter-hemispheric asymmetry. EPVS volume increased with age, higher TIV and lower blood plasma osmolality levels. Our findings offer valuable insights into EPVS characteristics among the healthy population, establishing a foundation to further explore age-related and pathological changes.
- dc.format.mimetype application/pdf
- dc.identifier.citation Morozova A, Španiel F, Škoch A, Brabec M, Zolotarov G, Musil V, et al. Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study. Neuroimage. 2024 Oct 15;300:120871. DOI: 10.1016/j.neuroimage.2024.120871
- dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2024.120871
- dc.identifier.issn 1053-8119
- dc.identifier.uri http://hdl.handle.net/10230/68932
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Neuroimage. 2024 Oct 15;300:120871
- dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Blood plasma osmolality
- dc.subject.keyword Glymphatic system
- dc.subject.keyword Interhemispheric asymmetry
- dc.subject.keyword Perivascular spaces
- dc.subject.keyword Total intracranial volume
- dc.title Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion