Clinical features of gastric signet ring cell cancer: results from a systematic review and meta-analysis
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Dal Cero, Mariagiulia
- dc.contributor.author Bencivenga, Maria
- dc.contributor.author Liu, Drolaiz H. W.
- dc.contributor.author Sacco, Michele
- dc.contributor.author Alloggio, Mariella
- dc.contributor.author Kerckhoffs, Kelly G. P.
- dc.contributor.author Filippini, Federica
- dc.contributor.author Saragoni, Luca
- dc.contributor.author Iglesias Coma, Mar
- dc.contributor.author Tomezzoli, Anna
- dc.contributor.author Carneiro, Fátima
- dc.contributor.author Grabsch, Heike I.
- dc.contributor.author Verlato, Giuseppe
- dc.contributor.author Torroni, Lorena
- dc.contributor.author Piessen, Guillaume
- dc.contributor.author Pera Roman, Manuel Ramón
- dc.contributor.author De Manzoni, Giovanni
- dc.date.accessioned 2024-03-14T07:22:58Z
- dc.date.available 2024-03-14T07:22:58Z
- dc.date.issued 2023
- dc.description.abstract Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer compared with other histologies. Methods: A systematic literature search in the PubMed database was conducted, including all publications up to 1 October 2021. A meta-analysis comparing the results of the studies was performed. Results: A total of 2062 studies referring to gastric cancer with signet ring cell histology were identified, of which 262 studies reported on its relationship with clinical information. Of these, 74 were suitable to be included in the meta-analysis. A slightly lower risk of developing nodal metastases in signet ring cell tumours compared to other histotypes was found (especially to undifferentiated/poorly differentiated/mucinous and mixed histotypes); the lower risk was more evident in early and slightly increased in advanced gastric cancer. Survival tended to be better in early stage signet ring cell cancer compared to other histotypes; no differences were shown in advanced stages, and survival was poorer in metastatic patients. In the subgroup analysis, survival in signet ring cell cancer was slightly worse compared to non-signet ring cell cancer and differentiated/well-to-moderately differentiated adenocarcinoma. Conclusions: Most of the conflicting results in signet ring cell gastric cancer literature could be derived from the lack of standardisation in their classification and the comparison with the different subtypes of gastric cancer. There is a critical need to strive for a standardised classification system for gastric cancer, fostering clarity and coherence in the forthcoming research and clinical applications.
- dc.format.mimetype application/pdf
- dc.identifier.citation Dal Cero M, Bencivenga M, Liu DHW, Sacco M, Alloggio M, Kerckhoffs KGP, Filippini F, Saragoni L, Iglesias M, Tomezzoli A, Carneiro F, Grabsch HI, Verlato G, Torroni L, Piessen G, Pera M, de Manzoni G. Clinical features of gastric signet ring cell cancer: results from a systematic review and meta-analysis. Cancers (Basel). 2023 Oct 28;15(21):5191. DOI: 10.3390/cancers15215191
- dc.identifier.doi http://dx.doi.org/10.3390/cancers15215191
- dc.identifier.issn 2072-6694
- dc.identifier.uri http://hdl.handle.net/10230/59406
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Cancers (Basel). 2023 Oct 28;15(21):5191
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Gastric cancer
- dc.subject.keyword Pathological classification
- dc.subject.keyword Poorly cohesive
- dc.subject.keyword Signet ring cells
- dc.subject.keyword Survival
- dc.title Clinical features of gastric signet ring cell cancer: results from a systematic review and meta-analysis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion