Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems

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• dc.contributor.author Lozano, Manuel
• dc.contributor.author Broberg, Karin
• dc.contributor.author Soler Blasco, Raquel
• dc.contributor.author Riutort-Mayol, Gabriel
• dc.contributor.author Ballester Díez, Ferran
• dc.contributor.author González-Safont, Llúcia
• dc.contributor.author Murcia, Mario
• dc.contributor.author Grimalt Obrador, Joan
• dc.contributor.author Gil Hernández, Fernando
• dc.contributor.author Olmedo, Pablo
• dc.contributor.author Braeuer, Simone
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Guxens Junyent, Mònica
• dc.contributor.author Irizar, Amaia
• dc.contributor.author Lertxundi, Nerea
• dc.contributor.author Zubero, Miren Begoña
• dc.contributor.author Santa Marina, Loreto
• dc.contributor.author Llop, Sabrina
• dc.date.accessioned 2023-11-15T07:15:59Z
• dc.date.available 2023-11-15T07:15:59Z
• dc.date.issued 2024
• dc.description.abstract Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) were measured in urine samples collected during pregnancy. Inorganic As metabolites were speciated in a subsample (n = 729). Emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL) composed of three scales: internalizing, externalizing and total problems. Sociodemographic, dietary and exposure to other environmental pollutants were obtained through questionnaires. Single nucleotide polymorphisms in brain- and metabolism-related genes APOE, BDNF, GSTP1, and PON1 were determined in cord blood. Multivariate negative binomial models were used. The interaction with sex and genotypes was evaluated including interaction terms. A multi-element analysis was carried out by a principal component analysis. Higher concentrations of Cu, monomethylarsonic acid, and Pb during pregnancy were associated with an increased incidence ratio risk (IRR) between 4.6 and 7.5% for internalizing and externalizing problems for all three CBCL scales in the children. Increasing Mo, Ni and Co concentrations were associated with higher IRR for internalizing problems (up to 8%), and Cd for externalizing problems (6.7%). Modifications by sex and genotypes were found for several associations. Multi-element analysis associated multiple metals and trace elements (Ni, Cu, Se, Cd and Pb) with higher internalizing problems.
• dc.description.sponsorship This study was supported by grants from Spanish government through the Ministry of Universities under the grant CAS21/00008 and grant for the requalification of the Spanish University, financed by the European Union, NextGeneration EU, Instituto de Salud Carlos III [FIS-FEDER: 13/1944, 16/1288, 17/00663 and 19/1338; FIS-FSE: 17/00260; Miguel Servet-FSE: MSII20/0006, FIS-PI06/0867, FIS-PI09/00090, CPII18/00018], CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089, 2015111065), Generalitat Valenciana [BEST/2020/059, AICO/2020/285 and CIAICO/2021/132] and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221 and DFG 89/17). We also acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
• dc.format.mimetype application/pdf
• dc.identifier.citation Lozano M, Broberg K, Soler-Blasco R, Riutort-Mayol G, Ballester F, González L, Murcia M, Grimalt JO, Gil F, Olmedo P, Braeuer S, Casas M, Guxens M, Irizar A, Lertxundi N, Santa Marina L, Llop S. Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems. Expo Health. 2024;16:679–92. DOI: 10.1007/s12403-023-00585-6
• dc.identifier.doi http://dx.doi.org/10.1007/s12403-023-00585-6
• dc.identifier.issn 2451-9766
• dc.identifier.uri http://hdl.handle.net/10230/58268
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Expo Health. 2024;16:679–92
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Metals
• dc.subject.keyword Arsenic speciation
• dc.subject.keyword Trace elements
• dc.subject.keyword Emotional and behavioral problems
• dc.subject.keyword Prenatal exposure
• dc.title Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion