Airway hyperresponsiveness to mannitol in obesity before and after bariatric surgery

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• dc.contributor.author Arismendi, Ebymar
• dc.contributor.author Rivas, Eva
• dc.contributor.author Vidal Alaball, Josep
• dc.contributor.author Barreiro Portela, Esther
• dc.contributor.author Torralba, Yolanda
• dc.contributor.author Burgos, Felip
• dc.contributor.author Rodríguez-Roisin, Robert
• dc.date.accessioned 2023-06-27T06:11:07Z
• dc.date.available 2023-06-27T06:11:07Z
• dc.date.issued 2015
• dc.description.abstract The relationship between airway hyperresponsiveness (AHR) and obesity, a low-grade systemic inflammatory condition, remains largely unknown. It is established that AHR to indirect stimuli is associated with active airway inflammation. The objectives were to investigate the rate of AHR to mannitol in obese subjects and its changes 1 year after bariatric surgery (BS). We enrolled 58 candidates to BS severely obese (33 nonsmokers and 25 smokers) without history of asthma and 20 healthy, nonobese participants and related AHR to functional findings and serum and exhaled biomarkers. Before surgery, AHR was observed in 16 (28 %) obese with the provocation doses of mannitol to induce a 15 % fall in FEV1 (PD15) of (geometric mean [95 % CI]) 83 (24–145) mg. Compared to control participants, obese participants had lower spirometric values and higher serum and exhaled biomarkers (p < 0.05 each). After surgery, AHR was abolished (p < 0.01) in all but four obese subjects. Weight loss induced by BS was the key independent factor associated to AHR improvement. AHR to mannitol is highly prevalent in obesity, and it is largely abolished by BS.
• dc.format.mimetype application/pdf
• dc.identifier.citation Arismendi E, Rivas E, Vidal J, Barreiro E, Torralba Y, Burgos F, et al. Airway hyperresponsiveness to mannitol in obesity before and after bariatric surgery. Obesity Surgery. 2015 Sep;25(9):1666-71. DOI: 10.1007/s11695-014-1564-8
• dc.identifier.doi http://dx.doi.org/10.1007/s11695-014-1564-8
• dc.identifier.issn 0960-8923
• dc.identifier.uri http://hdl.handle.net/10230/57350
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Obesity Surgery. 2015 Sep;25(9):1666-71
• dc.rights This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/deed.es
• dc.subject.keyword Abdominal obesity
• dc.subject.keyword Airway inflammation
• dc.subject.keyword Bronchial hyperreactivity
• dc.subject.keyword Indirect bronchoconstrictor
• dc.subject.keyword Systemic inflammation
• dc.title Airway hyperresponsiveness to mannitol in obesity before and after bariatric surgery
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion