Dynamical feature extraction at the sensory periphery guides chemotaxis
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- dc.contributor.author Schulze, Aljoscha, 1980-ca
- dc.contributor.author Gómez Marín, Alexca
- dc.contributor.author Rajendran, Vani G.ca
- dc.contributor.author Lott, Gusca
- dc.contributor.author Musy, Marcoca
- dc.contributor.author Ahammad, Parvezca
- dc.contributor.author Deogade, Ajinkya, 1989-ca
- dc.contributor.author Sharpe, Jamesca
- dc.contributor.author Riedl, Julia, 1981-ca
- dc.contributor.author Jarriault, Davidca
- dc.contributor.author Trautman, Eric T.ca
- dc.contributor.author Werner, Christopherca
- dc.contributor.author Venkadesan, Madhusudhanca
- dc.contributor.author Druckmann, Shaulca
- dc.contributor.author Jayaraman, Vivekca
- dc.contributor.author Louis, Matthieuca
- dc.date.accessioned 2015-11-10T14:22:48Z
- dc.date.available 2015-11-10T14:22:48Z
- dc.date.issued 2015
- dc.description.abstract Behavioral strategies employed for chemotaxis have been described across phyla, but the sensorimotor basis of this phenomenon has seldom been studied in naturalistic contexts. Here, we examine how signals experienced during free olfactory behaviors are processed by first-order olfactory sensory neurons (OSNs) of the Drosophila larva. We find that OSNs can act as differentiators that transiently normalize stimulus intensity—a property potentially derived from a combination of integral feedback and feed-forward regulation of olfactory transduction. In olfactory virtual reality experiments, we report that high activity levels of the OSN suppress turning, where as low activity levels facilitate turning. Using a generalized linear model, we explain how peripheral encoding of olfactory stimuli modulates the probability of switching from a run to a turn. Our work clarifies the link between computations carried out at the sensory periphery and action selection underlying navigation in odor gradients.en
- dc.description.sponsorship This work was supported by the EU project “Marie-Curie Action: Initial Training Networks” (EC FP7-PEOPLE-2011-ITN, grant number 289941).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Schulze A, Gomez-Marin A, Rajendran VG, Lott G, Musy M, Ahammad P, Deogade A et al. Dynamical feature extraction at the sensory periphery guides chemotaxis. eLife. 2015;4:e06694. DOI: 10.7554/eLife.06694.001ca
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.06694.001
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/25034
- dc.language.iso engca
- dc.publisher eLifeca
- dc.relation.ispartof eLife. 2015;4:e06694
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289941
- dc.rights Copyright Schulze et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Drosòfila -- Genèticaca
- dc.subject.other Neurones sensorialsca
- dc.title Dynamical feature extraction at the sensory periphery guides chemotaxisen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca