Aurora-A regulates MCRS1 function during mitosis

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dc.contributor.authorMeunier, Sylvainca
dc.contributor.authorTimón Pérez, Krystal, 1987-ca
dc.contributor.authorVernos, Isabelle, 1959-ca
dc.date.accessioned2017-04-19T07:21:00Z
dc.date.available2017-04-19T07:21:00Z
dc.date.issued2016
dc.description.abstractThe mitotic spindle is made of microtubules (MTs) nucleated through different pathways involving the centrosomes, the chromosomes or the walls of pre-existing MTs. MCRS1 is a RanGTP target that specifically associates with the chromosome-driven MTs protecting them from MT depolymerases. MCRS1 is also needed for the control of kinetochore fiber (K-fiber) MT minus-ends dynamics in metaphase. Here, we investigated the regulation of MCRS1 activity in M-phase. We show that MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36. Although this phosphorylation has no role on MCRS1 localization to chromosomal MTs and K-fiber minus-ends, we show that it regulates MCRS1 activity in mitosis. We conclude that Aurora-A activity is particularly important in the tuning of K-fiber minus-ends dynamics in mitosis.
dc.format.mimetypeapplication/pdfca
dc.identifier.citationMeunier S, Timón Pérez K, Vernos I. Aurora-A regulates MCRS1 function during mitosis. Cell Cycle. 2016;15(13):1779-86. DOI: 10.1080/15384101.2016.1187342
dc.identifier.doihttp://dx.doi.org/10.1080/15384101.2016.1187342
dc.identifier.issn1538-4101
dc.identifier.urihttp://hdl.handle.net/10230/30833
dc.language.isoeng
dc.publisherTaylor & Francis (Routledge)ca
dc.relation.ispartofCell Cycle. 2016;15(13):1779-86
dc.rights© 2016 The Author(s). Published with license by Taylor & Francis.© Sylvain Meunier, Krystal Timon, and Isabelle Vernos. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.subject.keywordAurora-A kinase
dc.subject.keywordChromosomal microtubules
dc.subject.keywordK-fiber
dc.subject.keywordMCRS1
dc.subject.keywordMicrotubule minus-end
dc.subject.keywordMitosis
dc.subject.keywordPhosphorylation
dc.titleAurora-A regulates MCRS1 function during mitosisca
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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