Endosomal acidification inhibitors for the treatment of BRAF mutant tumors.

Espinosa Blay, Lluís

doi:http://dx.doi.org/10.1080/23723556.2015.1062073

Endosomal acidification inhibitors for the treatment of BRAF mutant tumors.

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Espinosa L. Endosomal acidification inhibitors for the treatment of BRAF mutant tumors. Mol Cell Oncol. 2015 Nov 18;3(2):e1062073. doi: 10.1080/23723556.2015.1062073

Abstract

Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphorylation of p45-IKKα and abolish the metastatic capacity of BRAF mutant cancer cells.