Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1

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  • dc.contributor.author Herrmann, Madeleineca
  • dc.contributor.author Ruprecht, Klemensca
  • dc.contributor.author Sauter, Marliesca
  • dc.contributor.author Martinez, Javier P.ca
  • dc.contributor.author van Heteren, Pearlca
  • dc.contributor.author Glas, Michaelca
  • dc.contributor.author Best, Barbaraca
  • dc.contributor.author Meyerhans, Andreasca
  • dc.contributor.author Roemer, Klausca
  • dc.contributor.author Mueller-Lantzsch, Nikolausca
  • dc.date.accessioned 2016-01-15T18:20:51Z
  • dc.date.available 2016-01-15T18:20:51Z
  • dc.date.issued 2010
  • dc.description.abstract Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) to the cytoplasmic C-terminus of the voltage-gated potassium channel BEC1 (brain-specific ether-a-go-go-like channel 1), an interaction that can result in the repression of BEC's activity and the inhibition of HIV-1 particle-release. BEC1 protein was found to be expressed in T cells and macrophages, the major target cells of HIV-1. Thus, gp120/BEC1 interaction may be involved in HIV-1 life cycle and/or pathogenesis.ca
  • dc.description.sponsorship This study was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) and Deutscher Akademischer Austauschdienst (DAAD).
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Herrmann M, Ruprecht K, Sauter M, Martinez J, van Heteren P, Glas M et al. Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1. FEBS Letters. 2010;584(16):3513-8. DOI: 10.1016/j.febslet.2010.07.016ca
  • dc.identifier.doi http://dx.doi.org/10.1016/j.febslet.2010.07.016
  • dc.identifier.issn 0014-5793
  • dc.identifier.uri http://hdl.handle.net/10230/25585
  • dc.language.iso engca
  • dc.publisher Elsevierca
  • dc.relation.ispartof FEBS Letters. 2010;584(16):3513-8
  • dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.febslet.2010.07.016 that appeared in the journal FEBS Letters. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.keyword Human immunodeficiency virus
  • dc.subject.keyword Immunodeficiency virus
  • dc.subject.keyword Glycoprotein 120
  • dc.subject.other VIH (Virus)ca
  • dc.subject.other RNA missatgerca
  • dc.title Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca