Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1
| dc.contributor.author | Herrmann, Madeleine | ca |
| dc.contributor.author | Ruprecht, Klemens | ca |
| dc.contributor.author | Sauter, Marlies | ca |
| dc.contributor.author | Martinez, Javier P. | ca |
| dc.contributor.author | van Heteren, Pearl | ca |
| dc.contributor.author | Glas, Michael | ca |
| dc.contributor.author | Best, Barbara | ca |
| dc.contributor.author | Meyerhans, Andreas | ca |
| dc.contributor.author | Roemer, Klaus | ca |
| dc.contributor.author | Mueller-Lantzsch, Nikolaus | ca |
| dc.date.accessioned | 2016-01-15T18:20:51Z | |
| dc.date.available | 2016-01-15T18:20:51Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) to the cytoplasmic C-terminus of the voltage-gated potassium channel BEC1 (brain-specific ether-a-go-go-like channel 1), an interaction that can result in the repression of BEC's activity and the inhibition of HIV-1 particle-release. BEC1 protein was found to be expressed in T cells and macrophages, the major target cells of HIV-1. Thus, gp120/BEC1 interaction may be involved in HIV-1 life cycle and/or pathogenesis. | ca |
| dc.description.sponsorship | This study was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) and Deutscher Akademischer Austauschdienst (DAAD). | |
| dc.format.mimetype | application/pdf | ca |
| dc.identifier.citation | Herrmann M, Ruprecht K, Sauter M, Martinez J, van Heteren P, Glas M et al. Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1. FEBS Letters. 2010;584(16):3513-8. DOI: 10.1016/j.febslet.2010.07.016 | ca |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.febslet.2010.07.016 | |
| dc.identifier.issn | 0014-5793 | |
| dc.identifier.uri | http://hdl.handle.net/10230/25585 | |
| dc.language.iso | eng | ca |
| dc.publisher | Elsevier | ca |
| dc.relation.ispartof | FEBS Letters. 2010;584(16):3513-8 | |
| dc.rights | © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.febslet.2010.07.016 that appeared in the journal FEBS Letters. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license | ca |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
| dc.subject.keyword | Human immunodeficiency virus | |
| dc.subject.keyword | Immunodeficiency virus | |
| dc.subject.keyword | Glycoprotein 120 | |
| dc.subject.other | VIH (Virus) | ca |
| dc.subject.other | RNA missatger | ca |
| dc.title | Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1 | ca |
| dc.type | info:eu-repo/semantics/article | ca |
| dc.type.version | info:eu-repo/semantics/publishedVersion | ca |
Files
Original bundle
1 - 1 of 1