BacFITBase: a database to assess the relevance of bacterial genes during host infection

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  • dc.contributor.author Macho Rendón, Javier
  • dc.contributor.author Lang, Benjamin
  • dc.contributor.author Tartaglia, Gian Gaetano
  • dc.contributor.author Torrent Burgas, Marc
  • dc.date.accessioned 2020-04-27T10:21:50Z
  • dc.date.available 2020-04-27T10:21:50Z
  • dc.date.issued 2020
  • dc.description.abstract Bacterial infections have been on the rise world-wide in recent years and have a considerable impact on human well-being in terms of attributable deaths and disability-adjusted life years. Yet many mechanisms underlying bacterial pathogenesis are still poorly understood. Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets. BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host species. The data were collected from 15 different studies in which transposon mutagenesis was performed, including top-priority pathogens such as Acinetobacter baumannii and Campylobacter jejuni, for both of which increasing antibiotic resistance has been reported. Overall, BacFITBase includes information on 15 pathogenic bacteria and 5 host vertebrates across 10 different tissues. It is freely available at www.tartaglialab.com/bacfitbase.
  • dc.description.sponsorship This study was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades [SAF2015-72518-EXP, SAF2017-82158-R, RYC-2012-09999]; European Research Council [RIBOMYLOME_309545]; European Union's Horizon 2020 Research and Innovation Programme [727658, IASIS]; Spanish Ministry of Economy and Competitiveness [BFU2014-55054-P, BFU2017-86970-P]; Spanish Ministry of Economy and Competitiveness; ‘Centro de Excelencia Severo Ochoa 2013–2017’; CERCA Programme of the Generalitat de Catalunya; European Union's Horizon 2020 Research and Innovation Programme, Marie Sklodowska-Curie Individual Fellowship [793135, ‘DeepRNA’ to B.L.]; European Society of Clinical Microbiology and Infectious Diseases, Research Grant 2016 (ESCMID). Funding for open access charge: Spanish Ministerio de Ciencia, Innovación y Universidades [SAF2017-82158-R]
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Rendón JM, Lang B, Tartaglia GG2, Burgas MT. BacFITBase: a database to assess the relevance of bacterial genes during host infection. Nucleic Acids Res. 2020 Jan 8; 48(D1): D511-D516. DOI: 10.1093/nar/gkz931
  • dc.identifier.doi http://dx.doi.org/10.1093/nar/gkz931
  • dc.identifier.issn 0305-1048
  • dc.identifier.uri http://hdl.handle.net/10230/44343
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof Nucleic Acids Research. 2020 Jan 8; 48(D1): D511-D516
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/309545
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/727658
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/793135
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55054-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-72518-EXP
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-82158-R
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86970-P
  • dc.rights © 2020 Javier Macho Rendón et al. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Malalties bacterianes
  • dc.subject.other Proteïnes bacterials
  • dc.subject.other Antibiòtics
  • dc.title BacFITBase: a database to assess the relevance of bacterial genes during host infection
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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