Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials

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• dc.contributor.author Bettinardi, Ruggero G.ca
• dc.contributor.author Tort-Colet, Núriaca
• dc.contributor.author Ruiz Mejias, Marcelca
• dc.contributor.author Sanchez-Vives, Maria V.ca
• dc.contributor.author Deco, Gustavoca
• dc.date.accessioned 2016-04-22T09:02:26Z
• dc.date.available 2016-04-22T09:02:26Z
• dc.date.issued 2015ca
• dc.description.abstract Intrinsic brain activity is characterized by the presence of highly structured networks of correlated fluctuations between different regions of the brain. Such networks encompass different functions, whose properties are known to be modulated by the ongoing global brain state and are altered in several neurobiological disorders. In the present study, we induced a deep state of anesthesia in rats by means of a ketamine/medetomidine peritoneal injection, and analyzed the time course of the correlation between the brain activity in different areas while anesthesia spontaneously decreased over time. We compared results separately obtained from fMRI and local field potentials (LFPs) under the same anesthesia protocol, finding that while most profound phases of anesthesia can be described by overall sparse connectivity, stereotypical activity and poor functional integration, during lighter states different frequency-specific functional networks emerge, endowing the gradual restoration of structured large-scale activity seen during rest. Noteworthy, our in vivo results show that those areas belonging to the same functional network (the default-mode) exhibited sustained correlated oscillations around 10 Hz throughout the protocol, suggesting the presence of a specific functional backbone that is preserved even during deeper phases of anesthesia. Finally, the overall pattern of results obtained from both imaging and in vivo-recordings suggests that the progressive emergence from deep anesthesia is reflected by a corresponding gradual increase of organized correlated oscillations across the cortex.
• dc.description.sponsorship The research reported herein was supported by the ERC Advanced Grant DYSTRUCTURE (No. 295129), FET Flagship Human Brain Project, Brain Network Recovery Group through the James S. McDonnell Foundation (220020255), FP7-ICT BrainScales (No. 269921), CORONET (No. 269459), Ministerio de Economia y Competitividad (MINECO-PSI2013-42091-P), and Agència Gestió d'Ajuts Universitaris i de Recerca (2009SGR292) to G.D. M.V.S.V. was supported by the Ministerio de Economía y Competitividad (Spain)BFU2011-27094 and EU project CORTICONIC Contract number 600806.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Bettinardi RG, Tort-Colet N, Ruiz-Mejias M, Sanchez-Vives MV, Deco G. Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials. Neuroimage. 2015;114:185-198. doi:10.1016/j.neuroimage.2015.03.037ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2015.03.037
• dc.identifier.issn 1053-8119ca
• dc.identifier.uri http://hdl.handle.net/10230/26160
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof NeuroImage. 2015;114:185-198
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129ca
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269459
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/600806
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/604102
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-27094
• dc.rights © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Brain states
• dc.subject.keyword Connectivity
• dc.subject.keyword Anesthesia levels
• dc.subject.keyword Default-mode network
• dc.subject.keyword Alpha rhythm
• dc.subject.keyword Gamma rhythm
• dc.title Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentialsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca