The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
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- dc.contributor.author Merlos-Suárez, Annaca
- dc.contributor.author Barriga de Vicente, Francisco Martín, 1983-ca
- dc.contributor.author Jung, Peterca
- dc.contributor.author Iglesias Coma, Marca
- dc.contributor.author Céspedes, María Virtudesca
- dc.contributor.author Rossell, Davidca
- dc.contributor.author Sevillano, Martaca
- dc.contributor.author Hernando-Momblona, Xavierca
- dc.contributor.author Silva-Diz, Victoria daca
- dc.contributor.author Muñoz, Purificaciónca
- dc.contributor.author Clevers, Hansca
- dc.contributor.author Sancho, Elenaca
- dc.contributor.author Mangues, Ramonca
- dc.contributor.author Batlle Gómez, Eduardca
- dc.date.accessioned 2015-07-15T06:57:57Z
- dc.date.available 2015-07-15T06:57:57Z
- dc.date.issued 2011ca
- dc.description.abstract A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients. ISCs are marked by high expression of the EphB2 receptor, which becomes gradually silenced as cells differentiate. Using EphB2 and the ISC marker Lgr5, we have FACS-purified and profiled mouse ISCs, crypt proliferative progenitors, and late transient amplifying cells to define a gene program specific for normal ISCs. Furthermore, we discovered that ISC-specific genes identify a stem-like cell population positioned at the bottom of tumor structures reminiscent of crypts. EphB2 sorted ISC-like tumor cells display robust tumor-initiating capacity in immunodeficient mice as well as long-term self-renewal potential. Taken together, our data suggest that the ISC program defines a cancer stem cell niche within colorectal tumors and plays a central role in CRC relapse.
- dc.description.sponsorship This work has been supported by grants to E.B. from ERC (FP7-EU) and MICINN (Plan Nacional I+D+i and Consolider programs) and by grants PS09/00965 (MICINN) and NanoCoMets (CIBERBBN) to R.M
- dc.format.mimetype application/pdfca
- dc.identifier.citation Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell. 2011 May 6;8(5):511-24. DOI: 10.1016/j.stem.2011.02.020ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.stem.2011.02.020
- dc.identifier.issn 1934-5909ca
- dc.identifier.uri http://hdl.handle.net/10230/24598
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Cell Stem Cell. 2011 May 6;8(5):511-24
- dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.stem.2011.02.020 that appeared in the journal Cell Stem Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Cèl·lules mare adultes
- dc.subject.other Còlon -- Càncer -- Diagnòstic
- dc.subject.other Intestins
- dc.title The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapseca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca