TCS: a web server for multiple sequence alignment evaluation and phylogenetic reconstruction
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- dc.contributor.author Chang, Jia-Ming, 1978-ca
- dc.contributor.author Di Tommaso, Paoloca
- dc.contributor.author Lefort, Vincentca
- dc.contributor.author Gascuel, Olivierca
- dc.contributor.author Notredame, Cedricca
- dc.date.accessioned 2015-11-18T13:09:21Z
- dc.date.available 2015-11-18T13:09:21Z
- dc.date.issued 2015
- dc.description.abstract This article introduces the Transitive Consistency Score (TCS) web server; a service making it possible to estimate the local reliability of protein multiple sequence alignments (MSAs) using the TCS index. The evaluation can be used to identify the aligned positions most likely to contain structurally analogous residues and also most likely to support an accurate phylogenetic reconstruction. The TCS scoring scheme has been shown to be accurate predictor of structural alignment correctness among commonly used methods. It has also been shown to outperform common filtering schemes like Gblocks or trimAl when doing MSA post-processing prior to phylogenetic tree reconstruction. The web server is available from http://tcoffee.crg.cat/tcs.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Chang JM, Di Tommaso P, Lefort V, Gascuel O, Notredame C. TCS: a web server for multiple sequence alignment evaluation and phylogenetic reconstruction. Nucleic acids research. 2015;43(W1):W3-W6. DOI: 10.1093/nar/gkv310ca
- dc.identifier.doi http://dx.doi.org/10.1093/nar/gkv310
- dc.identifier.issn 0305-1048
- dc.identifier.uri http://hdl.handle.net/10230/25135
- dc.language.iso engca
- dc.publisher Oxford University Pressca
- dc.relation.ispartof Nucleic acids research. 2015;43(W1):W3-W6
- dc.rights © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Servidors web
- dc.subject.other Filogènia
- dc.title TCS: a web server for multiple sequence alignment evaluation and phylogenetic reconstructionca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca