A user's guide to the Encyclopedia of DNA elements (ENCODE)
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- dc.contributor.author Guigó Serra, Rodericca
- dc.contributor.author Myers, Richard M.ca
- dc.contributor.author Good, Peter Jca
- dc.date.accessioned 2015-04-14T07:11:55Z
- dc.date.available 2015-04-14T07:11:55Z
- dc.date.issued 2011ca
- dc.description.abstract The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.en
- dc.description.sponsorship Funded by the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. The role of the NIH Project Management Group in the preparation of this paper was limited to coordination and scientific management of the ENCODE Consortiumen
- dc.format.mimetype application/pdfca
- dc.identifier.citation Meyer LR, Sloan CA, Malladi VS, Cline MS, Learned K, Swing VK et al. A user's guide to the Encyclopedia of DNA elements (ENCODE). PLoS Biology. 2011; 9(4): e1001046. DOI 10.1371/journal.pbio.1001046ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.1001046
- dc.identifier.issn 1544-9173ca
- dc.identifier.uri http://hdl.handle.net/10230/23419
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS Biology. 2011; 9(4): e1001046
- dc.rights © 2011 The ENCODE Project Consortium. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Proteïnes de la sang -- Aspectes genèticsca
- dc.subject.other Genoma humàca
- dc.title A user's guide to the Encyclopedia of DNA elements (ENCODE)en
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca