Nicotine anxiogenic and rewarding effects are decreased in mice lacking β-endorphin

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• dc.contributor.author Trigo i Rodríguez, Josep M.
• dc.contributor.author Zimmer, Andreas
• dc.contributor.author Maldonado, Rafael, 1961-
• dc.date.accessioned 2019-02-25T08:52:03Z
• dc.date.available 2019-02-25T08:52:03Z
• dc.date.issued 2009
• dc.description.abstract The endogenous opioid system plays an important role in the behavioral effects of nicotine. Thus, micro-opioid receptor and the endogenous opioids derived from proenkephalin are involved in the central effects of nicotine. However, the role played by the different endogenous opioid peptides in the acute and chronic effects of nicotine remains to be fully established. Mice lacking beta-endorphin were acutely injected with nicotine at different doses to evaluate locomotor, anxiogenic and antinociceptive responses. The rewarding properties of nicotine were evaluated by using the conditioned place-preference paradigm. Mice chronically treated with nicotine were acutely injected with mecamylamine to study the behavioral expression of nicotine withdrawal. Mice lacking beta-endorphin exhibited a spontaneous hypoalgesia and hyperlocomotion and a reduction on the anxiogenic and rewarding effects induced by nicotine. Nicotine induced similar antinociception and hypolocomotion in both genotypes and no differences were found in the development of physical dependence. The dissociation between nicotine rewarding properties and physical dependence suggests a differential implication of beta-endorphin in these addictive related responses.
• dc.description.sponsorship This work was supported by NIDA (1R01-DA01 6768-0111), Ministerio de Ciencia y Tecnología (SAF2007-64062), Instituto de Salud Carlos III Red de Trastornos Adictivos, Generalitat de Catalunya (2005SGR00131 and ICREA Academia). European Commission (GENADDICT OJ 2004/C164, N005166 and PHECOMP LSHM-CT-2007-037669).
• dc.format.mimetype application/pdf
• dc.identifier.citation Trigo JM, Zimmer A, Maldonado R. Nicotine anxiogenic and rewarding effects are decreased in mice lacking β-endorphin. Neuropharmacology. 2009;56(8):1147-53. DOI: 10.1016/j.neuropharm.2009.03.013
• dc.identifier.doi http://dx.doi.org/10.1016/j.neuropharm.2009.03.013
• dc.identifier.issn 0028-3908
• dc.identifier.uri http://hdl.handle.net/10230/36668
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Neuropharmacology. 2009;56(8):1147-53
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.neuropharm.2009.03.013
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Reward
• dc.subject.keyword Dependence
• dc.subject.keyword Antinociception
• dc.subject.keyword Anxiety
• dc.subject.keyword Proopiomelanocortin
• dc.title Nicotine anxiogenic and rewarding effects are decreased in mice lacking β-endorphin
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion