Existence and dynamics of strains in a nonlocal reaction-diffusion model of viral evolution
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- dc.contributor.author Bessonov, Nickolay
- dc.contributor.author Bocharov, Gennady A.
- dc.contributor.author Meyerhans, Andreas
- dc.contributor.author Popov, Vladimir
- dc.contributor.author Volpert, Vitaly
- dc.date.accessioned 2022-03-17T10:47:46Z
- dc.date.available 2022-03-17T10:47:46Z
- dc.date.issued 2021
- dc.description.abstract In this work, we develop a mathematical framework for predicting and quantifying virus diversity evolution during infection of a host organism. It is specified as a virus density distribution with respect to genotype and time governed by a reaction-diffusion integro-differential equation taking virus mutations, replication, and elimination by immune cells and medical treatment into account. Conditions for the existence of virus strains that correspond to localized density distributions in the space of genotypes are determined. It is shown that common viral evolutionary traits like diversification and extinction are driven by nonlocal interactions via immune responses, target-cell competition, and therapy. This provides us with a mechanistic explanation for clinically relevant properties like immune escape and drug resistance selection, and allows us to link virus genotypes to phenotypes.
- dc.format.mimetype application/pdf
- dc.identifier.citation Bessonov N, Bocharov G, Meyerhans A, Popov V, Volper V. Existence and dynamics of strains in a nonlocal reaction-diffusion model of viral evolution. SIAM J Appl Math. 2021;81(1):107–28. DOI: 10.1137/19M1282234
- dc.identifier.doi http://dx.doi.org/10.1137/19M1282234
- dc.identifier.issn 0036-1399
- dc.identifier.uri http://hdl.handle.net/10230/52711
- dc.language.iso eng
- dc.publisher Society for Industrial and Applied Mathematics
- dc.rights © 2021, Society for Industrial and Applied Mathematics
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Virus -- Evolució
- dc.subject.other Genotip
- dc.subject.other Fenotip
- dc.subject.other Matemàtica
- dc.title Existence and dynamics of strains in a nonlocal reaction-diffusion model of viral evolution
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion