A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber

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  • dc.contributor.author Gómez‑Barea, Mario
  • dc.contributor.author Garcia-Sanchez, Tomas
  • dc.contributor.author Ivorra Cano, Antoni, 1974-
  • dc.date.accessioned 2023-02-07T07:37:37Z
  • dc.date.available 2023-02-07T07:37:37Z
  • dc.date.issued 2022
  • dc.description.abstract Pulsed Field Ablation (PFA) has been developed over the last years as a novel electrical ablation technique for treating cardiac arrhythmias. It is based on irreversible electroporation which is a non-thermal phenomenon innocuous to the extracellular matrix and, because of that, PFA is considered to be safer than the reference technique, Radiofrequency Ablation (RFA). However, possible differences in lesion morphology between both techniques have been poorly studied. Simulations including electric, thermal and fluid physics were performed in a simplified model of the cardiac chamber which, in essence, consisted of a slab of myocardium with blood in motion on the top. Monopolar and bipolar catheter configurations were studied. Different blood velocities and catheter orientations were assayed. RFA was simulated assuming a conventional temperature-controlled approach. The PFA treatment was assumed to consist in a sequence of 20 biphasic bursts (100 µs duration). Simulations indicate that, for equivalent lesion depths, PFA lesions are wider, larger and more symmetrical than RFA lesions for both catheter configurations. RFA lesions display a great dependence on blood velocity while PFA lesions dependence is negligible on it. For the monopolar configuration, catheter angle with respect to the cardiac surface impacted both ablation techniques but in opposite sense. The orientation of the catheter with respect to blood flow direction only affected RFA lesions. In this study, substantial morphological differences between RFA and PFA lesions were predicted numerically. Negligible dependence of PFA on blood flow velocity and direction is a potential important advantage of this technique over RFA.
  • dc.description.sponsorship This work was partially supported by project (PID2019-110120RBI00/AEI/10.13039/501100011033) from the Ministry of Science, Innovation and Universities and the State Research Agency of the Spanish government. Mario Gómez-Barea research is supported by a scholarship from the UPF. Tomás García-Sánchez acknowledges the funding received from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 892393 (TACAIRE). Antoni Ivorra gratefully acknowledges the financial support by ICREA under the ICREA Academia programme.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Gómez‑Barea M, García‑Sánchez T, Ivorra A. A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber. Sci Rep. 2022;12:16144. DOI: 10.1038/s41598-022-20212-9
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-022-20212-9
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/55654
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Scientific Reports. 2022;12:16144.
  • dc.relation.isreferencedby http://dx.doi.org/10.1038/s41598-022-20212-9
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/892393
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RBI00
  • dc.rights © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Enginyeria biomèdica
  • dc.subject.other Cardiologia
  • dc.title A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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