Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium

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• dc.contributor.author Küpers, Leanne K.
• dc.contributor.author Fernández-Barrés, Sílvia
• dc.contributor.author Nounu, Aayah
• dc.contributor.author Friedman, Chloe
• dc.contributor.author Fore, Ruby
• dc.contributor.author Mancano, Giulia
• dc.contributor.author Dabelea, Dana
• dc.contributor.author Rifas-Shiman, Sheryl L.
• dc.contributor.author Mulder, Rosa H.
• dc.contributor.author Oken, Emily
• dc.contributor.author Johnson, Laura
• dc.contributor.author Bustamante Pineda, Mariona
• dc.contributor.author Jaddoe, Vincent W. V.
• dc.contributor.author Hivert, Marie-France
• dc.contributor.author Starling, Anne P.
• dc.contributor.author de Vries, Jeanne H. M.
• dc.contributor.author Sharp, Gemma C.
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Felix, Janine Frédérique
• dc.date.accessioned 2022-05-19T05:52:32Z
• dc.date.available 2022-05-19T05:52:32Z
• dc.date.issued 2022
• dc.description.abstract Higher adherence to the Mediterranean diet during pregnancy is related to a lower risk of preterm birth and to better offspring cardiometabolic health. DNA methylation may be an underlying biological mechanism. We evaluated whether maternal adherence to the Mediterranean diet was associated with offspring cord blood DNA methylation.We meta-analysed epigenome-wide association studies (EWAS) of maternal adherence to the Mediterranean diet during pregnancy and offspring cord blood DNA methylation in 2802 mother-child pairs from five cohorts. We calculated the relative Mediterranean diet (rMED) score with range 0-18 and an adjusted rMED excluding alcohol (rMEDp, range 0-16). DNA methylation was measured using Illumina 450K arrays. We used robust linear regression modelling adjusted for child sex, maternal education, age, smoking, body mass index, energy intake, batch, and cell types. We performed several functional analyses and examined the persistence of differential DNA methylation into childhood (4.5-7.8 y).rMEDp was associated with cord blood DNA methylation at cg23757341 (0.064% increase in DNA methylation per 1-point increase in the rMEDp score, SE = 0.011, P = 2.41 × 10-8). This cytosine-phosphate-guanine (CpG) site maps to WNT5B, associated with adipogenesis and glycaemic phenotypes. We did not identify associations with childhood gene expression, nor did we find enriched biological pathways. The association did not persist into childhood.In this meta-analysis, maternal adherence to the Mediterranean diet (excluding alcohol) during pregnancy was associated with cord blood DNA methylation level at cg23757341. Potential mediation of DNA methylation in associations with offspring health requires further study.
• dc.description.sponsorship This work was supported by the Foundation for the National Institutes of Health [R01 HD034568, UH3 OD023286, R01 NR013945, R01 HL111108]; Joint Programming Initiative A healthy diet for a healthy life [529051023, MR/S036520/1, 529051022, MR/S036520/1, MR/S036520/1]; National Institute of Environmental Health Sciences [R00ES025817]; National institute of diabetes and digestive and kidney diseases [R01DK076648]; National Institutes of Health Office of the Director [UH3OD023248]; Horizon 2020 research and innovation [874739, 733206, 848158, 824989]; Medical Research Council [MR/S009310/1].
• dc.format.mimetype application/pdf
• dc.identifier.citation Küpers LK, Fernández-Barrés S, Nounu A, Friedman C, Fore R, Mancano G, Dabelea D, Rifas-Shiman SL, Mulder RH, Oken E, Johnson L, Bustamante M, Jaddoe VWV, Hivert MF, Starling AP, de Vries JHM, Sharp GC, Vrijheid M, Felix JF. Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium. Epigenetics. 2022 Nov;17(11):1419-31. DOI: 10.1080/15592294.2022.2038412
• dc.identifier.doi http://dx.doi.org/10.1080/15592294.2022.2038412
• dc.identifier.issn 1559-2294
• dc.identifier.uri http://hdl.handle.net/10230/53150
• dc.language.iso eng
• dc.publisher Taylor & Francis
• dc.relation.ispartof Epigenetics. 2022 Nov;17(11):1419-31
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874739
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848158
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
• dc.rights © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword DNA methylation
• dc.subject.keyword Epigenetics
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Cord blood
• dc.subject.keyword Epigenome-wide association study
• dc.subject.keyword Maternal diet
• dc.subject.keyword Newborn
• dc.subject.keyword Prenatal diet
• dc.title Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion