Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

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• dc.contributor.author Brotherton, Paul
• dc.contributor.author Cooper, Alan
• dc.contributor.author Genographic Consortium
• dc.contributor.author Bertranpetit, Jaume, 1952-
• dc.contributor.author Comas, David, 1969-
• dc.contributor.author Martínez Cruz, Begoña
• dc.contributor.author Mele, Marta
• dc.date.accessioned 2019-01-09T13:42:19Z
• dc.date.available 2019-01-09T13:42:19Z
• dc.date.issued 2013
• dc.description.abstract Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.
• dc.description.sponsorship We thank the Australian Research Council (grant LP0882622), the Deutsche Forschungsgemeinschaft (Al 287/7-1 and Me 3245/1-1) and National Geographic’s Genographic Project for funding
• dc.format.mimetype application/pdf
• dc.identifier.citation Brotherton P, Haak W, Templeton J, Brandt G, Soubrier J, Jane Adler C et al. Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. Nat Commun. 2013;4:1764. DOI: 10.1038/ncomms2656
• dc.identifier.doi http://dx.doi.org/10.1038/ncomms2656
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/36233
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature communications. 2013;4:1764
• dc.rights © Springer Nature Publishing AG. Brotherton P, Haak W, Templeton J, Brandt G, Soubrier J, Jane Adler C et al.Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. Nat Commun. 2013; 4: 1764. http://dx.doi.org/10.1038/ncomms2656
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Genoma humà
• dc.subject.other ADN mitocondrial
• dc.subject.other Haplotip
• dc.subject.other Filogènia
• dc.subject.other Neolític
• dc.subject.other Europeus
• dc.title Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion