Comparative metagenomics reveals poultry and swine farming are hotspots for multidrug and tetracycline resistance
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- dc.contributor.author Osorio, Victoria
- dc.contributor.author Sabater i Mezquita, Arnau
- dc.contributor.author Balcázar, José Luis
- dc.date.accessioned 2023-05-29T06:42:41Z
- dc.date.available 2023-05-29T06:42:41Z
- dc.date.issued 2023
- dc.description.abstract Antibiotic misuse in livestock is a major threat to human health, as bacteria are quickly developing resistance to them. We performed a comparative analysis of 25 faecal metagenomes from swine, poultry, cattle, and humans to investigate their resistance profiles. Our analysis revealed that all genes conferring resistance to antibiotic classes assessed except tetracyclines were more prevalent in poultry manure than in the remaining species. We detected clinically relevant antibiotic resistance genes, such as mcr-1 which confers resistance to polymyxins. Among them, extended-spectrum β-lactamase blaCTX-M genes were particularly abundant in all species. Poultry manure was identified as a hotspot for multidrug resistance, which may compromise medical treatment options. Urgent actions in the livestock industry are imperative to hamper the emergence and spread of antibiotic resistance.
- dc.format.mimetype application/pdf
- dc.identifier.citation Osorio V, Sabater A, Balcázar JL. Comparative metagenomics reveals poultry and swine farming are hotspots for multidrug and tetracycline resistance. Environmental Pollution. 2023 Apr 1;322:121239. DOI: 10.1016/j.envpol.2023.121239
- dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2023.121239
- dc.identifier.issn 0269-7491
- dc.identifier.uri http://hdl.handle.net/10230/57003
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Environmental Pollution. 2023 Apr 1;322:121239
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/801370
- dc.rights © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0
- dc.subject.keyword Antibiotic resistance genes
- dc.subject.keyword Mobile genetic elements
- dc.subject.keyword Livestock manure
- dc.subject.keyword Human medicine
- dc.subject.keyword One health
- dc.title Comparative metagenomics reveals poultry and swine farming are hotspots for multidrug and tetracycline resistance
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion