In the spotlight: the role of TGFβ signalling in haematopoietic stem and progenitor cell emergence

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• dc.contributor.author Thambyrajah, Roshana
• dc.contributor.author Monteiro, Rui
• dc.date.accessioned 2022-07-28T14:54:56Z
• dc.date.available 2022-07-28T14:54:56Z
• dc.date.issued 2022
• dc.description.abstract Haematopoietic stem and progenitor cells (HSPCs) sustain haematopoiesis by generating precise numbers of mature blood cells throughout the lifetime of an individual. In vertebrates, HSPCs arise during embryonic development from a specialised endothelial cell population, the haemogenic endothelium (HE). Signalling by the Transforming Growth Factor β (TGFβ) pathway is key to regulate haematopoiesis in the adult bone marrow, but evidence for a role in the formation of HSPCs has only recently started to emerge. In this review, we examine recent work in various model systems that demonstrate a key role for TGFβ signalling in HSPC emergence from the HE. The current evidence underpins two seemingly contradictory views of TGFβ function: as a negative regulator of HSPCs by limiting haematopoietic output from HE, and as a positive regulator, by programming the HE towards the haematopoietic fate. Understanding how to modulate the requirement for TGFβ signalling in HSC emergence may have critical implications for the generation of these cells in vitro for therapeutic use.
• dc.format.mimetype application/pdf
• dc.identifier.citation Thambyrajah R, Monteiro R. In the spotlight: the role of TGFβ signalling in haematopoietic stem and progenitor cell emergence. Biochem Soc Trans. 2022 Apr 29;50(2):703-12. DOI: 10.1042/BST20210363
• dc.identifier.doi http://dx.doi.org/10.1042/BST20210363
• dc.identifier.issn 0300-5127
• dc.identifier.uri http://hdl.handle.net/10230/53876
• dc.language.iso eng
• dc.publisher Portland Press
• dc.relation.ispartof Biochem Soc Trans. 2022 Apr 29;50(2):703-12
• dc.rights © 2022 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). Open access for this article was enabled by the participation of University of Birmingham in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword BMP
• dc.subject.keyword TGFβ
• dc.subject.keyword Endothelial to haematopoietic transition
• dc.subject.keyword Haemogenic endothelium
• dc.subject.keyword Mouse models
• dc.subject.keyword Zebrafish
• dc.title In the spotlight: the role of TGFβ signalling in haematopoietic stem and progenitor cell emergence
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion