Cortical microcircuit dynamics mediating binocular rivalry: the role of adaptation in inhibition

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• dc.contributor.author Theodoni, Panagiotaca
• dc.contributor.author Panagiotaropoulos, Theofanis I.ca
• dc.contributor.author Kapoor, Vishalca
• dc.contributor.author Logothetis, Nikosca
• dc.contributor.author Deco, Gustavoca
• dc.date.accessioned 2016-02-11T13:52:25Z
• dc.date.available 2016-02-11T13:52:25Z
• dc.date.issued 2011
• dc.description.abstract Perceptual bistability arises when two conflicting interpretations of an ambiguous stimulus or images in binocular rivalry (BR) compete for perceptual dominance. From a computational point of view, competition models based on cross-inhibition and adaptation have shown that noise is a crucial force for rivalry, and operates in balance with adaptation. In particular, noise-driven transitions and adaptation-driven oscillations define two dynamical regimes and the system explains the observed alternations in perception when it operates near their boundary. In order to gain insights into the microcircuit dynamics mediating spontaneous perceptual alternations, we used a reduced recurrent attractor-based biophysically realistic spiking network, well known for working memory, attention, and decision making, where a spike-frequency adaptation mechanism is implemented to account for perceptual bistability. We thus derived a consistently reduced four-variable population rate model using mean-field techniques, and we tested it on BR data collected from human subjects. Our model accounts for experimental data parameters such as mean time dominance, coefficient of variation, and gamma distribution fit. In addition, we show that our model operates near the bifurcation that separates the noise-driven transitions regime from the adaptation-driven oscillations regime, and agrees with Levelt’s second revised and fourth propositions. These results demonstrate for the first time that a consistent reduction of a biophysically realistic spiking network of leaky integrate-and-fire neurons with spike-frequency adaptation could account for BR. Moreover, we demonstrate that BR can be explained only through the dynamics of competing neuronal pools, without taking into account the adaptation of inhibitory interneurons. However, the adaptation of interneurons affects the optimal parametric space of the system by decreasing the overall adaptation necessary for the bifurcation to occur, and introduces oscillations in the spontaneous state.ca
• dc.description.sponsorship The authors would like to thank KongFatt Wong, Antoni Guillamon, James Rankin, Robert Ton, for their useful communications, and Tristan Nakagawa for his comments on the manuscript. The research leading to these results has received funding from the European Community’s Seventh Framework Programme FP7/2007-2013 under grant agreement number 214728-2, and the Max Planck Society. It was also supported by the European Union grant “Brainsynch” and “BrainScaleS” by the Spanish Research Project SAF2010-16085, and by the CONSOLIDER – INGENIO 2010 Programme CSD2007-00012.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Theodoni P, Panagiotaropoulos TI, Kapoor V, Logothetis NK, Deco G. Cortical microcircuit dynamics mediating binocular rivalry: the role of adaptation in inhibition. Front. Hum. Neurosci. 2011;145(5):1-19. DOI: 10.3389/fnhum.2011.00145.
• dc.identifier.doi http://dx.doi.org/10.3389/fnhum.2011.00145
• dc.identifier.issn 1662-5161
• dc.identifier.uri http://hdl.handle.net/10230/25788
• dc.language.iso engca
• dc.publisher Frontiers Mediaca
• dc.relation.ispartof Frontiers in human neuroscience 2011;145(5):1-19
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/214728
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012.
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
• dc.rights © 2011 Theodoni, Panagiotaropoulos, Kapoor, Logothetis and Deco. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/3.0/
• dc.subject.keyword Perceptual bistability
• dc.subject.keyword Binocular rivalry
• dc.subject.keyword Computational modeling
• dc.subject.keyword Spike-frequency adaptation
• dc.subject.keyword Spiking networks
• dc.subject.keyword Mean-field
• dc.title Cortical microcircuit dynamics mediating binocular rivalry: the role of adaptation in inhibitionca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca