FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.

Slebe Concha, Juan Felipe, 1981-; Rojo, Federico; Vinaixa, Maria; García-Rocha, Mar; Testoni, Giorgia; Guiu, Marc; Planet, Evarist; Samino, Sara; Arenas, Enrique J.; Beltran Marqués, Antoni; Rovira Guerín, Ana; Lluch, Ana; Salvatella, Xavier; Yanes, Oscar; Albanell Mestres, Joan; Guinovart, Joan J. (Joan Josep), 1947-; Gomis, Roger R.

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.

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dc.contributor.author Slebe Concha, Juan Felipe, 1981-ca
dc.contributor.author Rojo, Federicoca
dc.contributor.author Vinaixa, Mariaca
dc.contributor.author García-Rocha, Marca
dc.contributor.author Testoni, Giorgiaca
dc.contributor.author Guiu, Marcca
dc.contributor.author Planet, Evaristca
dc.contributor.author Samino, Saraca
dc.contributor.author Arenas, Enrique J.ca
dc.contributor.author Beltran Marqués, Antonica
dc.contributor.author Rovira Guerín, Anaca
dc.contributor.author Lluch, Anaca
dc.contributor.author Salvatella, Xavierca
dc.contributor.author Yanes, Oscarca
dc.contributor.author Albanell Mestres, Joanca
dc.contributor.author Guinovart, Joan J. (Joan Josep), 1947-ca
dc.contributor.author Gomis, Roger R.ca
dc.date.accessioned 2016-07-20T08:15:36Z
dc.date.available 2016-07-20T08:15:36Z
dc.date.issued 2016
dc.description.abstract The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.ca
dc.description.sponsorship F.S., E.J.A. and G.T. are supported by the ‘La Caixa’ PhD Fellowship Program. FIS PI12/00680, PI12/01421 and PI12/01552 supported J.A., A.L. and F.R., respectively. J.A. is part of RD12/0036/0051, RD12/0036/0070 and RD12/0036/0042 and F.R. part of biobank PT13/0010/0012. J.A. is the recipient of ISCIII intensification Grant 2014SGR740, XBTC, MARBiobanc and Cellex. R.R.G. was supported by the Institució Catalana de Recerca i Estudis Avançats. Support and structural funds were provided by the BBVA Foundation, the Generalitat de Catalunya (2014 SGR 535) and the Spanish Ministerio de Economia y Competitividad (MINECO) and FEDER funds (SAF2013-46196) to R.R.G. and (SAF2014-54525-P) to J.J.G.
dc.format.mimetype application/pdfca
dc.identifier.citation Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M et al. FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth. Nat Commun. 2016 Apr 5;7:11199. DOI: 10.1038/ncomms11199ca
dc.identifier.doi http://dx.doi.org/10.1038/ncomms11199
dc.identifier.issn 2041-1723
dc.identifier.uri http://hdl.handle.net/10230/27092
dc.language.iso engca
dc.publisher Nature Publishing Groupca
dc.relation.ispartof Nature Communications. 2016 Apr 5;7:11199
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-54525-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-46196
dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Càncer -- Aspectes genèticsca
dc.title FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)