Occupational solvent exposure and risk of glioma in the INTEROCC study

Benke, Geza; Turner, Michelle C.; Fleming, Sarah; Figuerola, Jordi; Kincl, Laurel; Richardson, Lesley; Blettner, Maria; Hours, Martine; Krewski, Daniel; McLean, Dave; Parent, Marie-Elise; Sadetzki, Siegal; Schlaefer, Klaus; Schlehofer, Brigitte; Siemiatycki, Jack; van Tongeren, Martie; Cardis, Elisabeth

Occupational solvent exposure and risk of glioma in the INTEROCC study

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dc.contributor.author Benke, Geza
dc.contributor.author Turner, Michelle C.
dc.contributor.author Fleming, Sarah
dc.contributor.author Figuerola, Jordi
dc.contributor.author Kincl, Laurel
dc.contributor.author Richardson, Lesley
dc.contributor.author Blettner, Maria
dc.contributor.author Hours, Martine
dc.contributor.author Krewski, Daniel
dc.contributor.author McLean, Dave
dc.contributor.author Parent, Marie-Elise
dc.contributor.author Sadetzki, Siegal
dc.contributor.author Schlaefer, Klaus
dc.contributor.author Schlehofer, Brigitte
dc.contributor.author Siemiatycki, Jack
dc.contributor.author van Tongeren, Martie
dc.contributor.author Cardis, Elisabeth
dc.date.accessioned 2023-06-27T06:19:49Z
dc.date.available 2023-06-27T06:19:49Z
dc.date.issued 2017
dc.description.abstract The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case–control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade. Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country–region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM. Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74–1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour. The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.
dc.format.mimetype application/pdf
dc.identifier.citation Benke G, Turner MC, Fleming S, Figuerola J, Kincl L, Richardson L, et al. Occupational solvent exposure and risk of glioma in the INTEROCC study. Br J Cancer. 2017 Oct;117(8):1246-54. DOI: 10.1038/bjc.2017.285
dc.identifier.doi http://dx.doi.org/10.1038/bjc.2017.285
dc.identifier.issn 0007-0920
dc.identifier.uri http://hdl.handle.net/10230/57359
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof British Journal of Cancer. 2017 Oct;117(8):1246-54
dc.rights From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.keyword Case–control study
dc.subject.keyword Glioma
dc.subject.keyword Occupation
dc.subject.keyword Solvent
dc.title Occupational solvent exposure and risk of glioma in the INTEROCC study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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