Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids
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- dc.contributor.author Puighermanal Puigvert, Emma, 1983-ca
- dc.contributor.author Busquets Garcia, Arnau, 1985-ca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Ozaita Mintegui, Andrés, 1969-ca
- dc.date.accessioned 2015-03-27T08:00:56Z
- dc.date.available 2015-03-27T08:00:56Z
- dc.date.issued 2012ca
- dc.description.abstract Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.
- dc.description.sponsorship EP is a recipient of an EMBO Fellowship with the support of European Commission (EMBOCOFUND2010, GA-2010-267146) and Marie Curie Actions. AB-G is a recipient of a predoctoral fellowship, Spanish Ministry of Education and Culture. This study was supported by grants from La Marató de TV3 (#090910 to AO), Grants from the Spanish Ministry of Science and Innovation (#SAF2009-07309 to AO and/n#SAF2011-29864 to RM); Instituto de Salud Carlos III (RD06/0001/0001 to RM); PLAN E (Plan Español para el Estímulo de la Economía y el Empleo); Generalitat de Catalunya (SGR-2009-00731 to RM and SGR-2009-00718 to RdlT); ICREA (Institució Catalana de Recerca i Estudis Avançats) Academia to RM
- dc.format.mimetype application/pdfca
- dc.identifier.citation Puighermanal E, Busquets-Garcia A, Maldonado R, Ozaita A. Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3254-63. DOI: 10.1098/rstb.2011.0384ca
- dc.identifier.doi http://dx.doi.org/10.1098/rstb.2011.0384
- dc.identifier.issn 0962-8436ca
- dc.identifier.uri http://hdl.handle.net/10230/23298
- dc.language.iso engca
- dc.publisher Royal Societyca
- dc.relation.ispartof Philosophical Transactions of the Royal Society B: Biological Sciences. 2012 Dec 5;367(1607):3254-63
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/267146
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-07309
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
- dc.rights © The Royal Society. http://dx.doi.org/10.1098/rstb.2011.0384ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Trastorns de la cognició
- dc.subject.other Cannabinoides
- dc.title Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoidsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca