Floating EMG sensors and stimulators wirelessly powered and operated by volume conduction for networked neuroprosthetics

Becerra Fajardo, Laura; Krob, Marc Oliver; Minguillon, Jesus; Rodrigues, Camila; Welsch, Christine; Tudela Pi, Marc; Comerma-Montells, Albert; Oliveira Barroso, Filipe; Schneider, Andreas; Ivorra Cano, Antoni, 1974-

doi:http://dx.doi.org/10.1186/s12984-022-01033-3

Floating EMG sensors and stimulators wirelessly powered and operated by volume conduction for networked neuroprosthetics

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Becerra-Fajardo L, Krob MO, Minguillon J, Rodrigues C, Welsch C, Tudela-Pi M, Comerma A, Oliveira Barroso F, Schneider A, Ivorra A. Floating EMG sensors and stimulators wirelessly powered and operated by volume conduction for networked neuroprosthetics. J Neuroeng Rehabil. 2022;19:57. DOI: 10.1186/s12984-022-01033-3

Abstract

Background: Implantable neuroprostheses consisting of a central electronic unit wired to electrodes benefit thousands of patients worldwide. However, they present limitations that restrict their use. Those limitations, which are more adverse in motor neuroprostheses, mostly arise from their bulkiness and the need to perform complex surgical implantation procedures. Alternatively, it has been proposed the development of distributed networks of intramuscular wireless microsensors and microstimulators that communicate with external systems for analyzing neuromuscular activity and performing stimulation or controlling external devices. This paradigm requires the development of miniaturized implants that can be wirelessly powered and operated by an external system. To accomplish this, we propose a wireless power transfer (WPT) and communications approach based on volume conduction of innocuous high frequency (HF) current bursts. The currents are applied through external textile electrodes and are collected by the wireless devices through two electrodes for powering and bidirectional digital communications. As these devices do not require bulky components for obtaining power, they may have a flexible threadlike conformation, facilitating deep implantation by injection. Methods: We report the design and evaluation of advanced prototypes based on the above approach. The system consists of an external unit, floating semi-implantable devices for sensing and stimulation, and a bidirectional communications protocol. The devices are intended for their future use in acute human trials to demonstrate the distributed paradigm. The technology is assayed in vitro using an agar phantom, and in vivo in hindlimbs of anesthetized rabbits. Results: The semi-implantable devices were able to power and bidirectionally communicate with the external unit. Using 13 commands modulated in innocuous 3 MHz HF current bursts, the external unit configured the sensing and stimulation parameters, and controlled their execution. Raw EMG was successfully acquired by the wireless devices at 1 ksps. Conclusions: The demonstrated approach overcomes key limitations of existing neuroprostheses, paving the way to the development of distributed flexible threadlike sensors and stimulators. To the best of our knowledge, these devices are the first based on WPT by volume conduction that can work as EMG sensors and as electrical stimulators in a network of wireless devices.