Available and affordable complementary treatments for COVID-19: From hypothesis to pilot studies and the need for implementation

Bousquet, Jean; Haahtela, Tari; Blain, Hubert; Czarlewski, Wienczyslawa; Zuberbier, Torsten; Bedbrook, Anna; Cruz, Alvaro A.; Fonseca, Joao A.; Klimek, Ludger; Kuna, Piotr; Samolinski, Boleslaw; Valiulis, Arunas; Lemaire, Antoine; Antó i Boqué, Josep Maria

doi:http://dx.doi.org/10.1002/clt2.12127

Available and affordable complementary treatments for COVID-19: From hypothesis to pilot studies and the need for implementation

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Bousquet J, Haahtela T, Blain H, Czarlewski W, Zuberbier T, Bedbrook A, Cruz AA, Fonseca JA, Klimek L, Kuna P, Samolinski B, Valiulis A, Lemaire A, Anto JM. Available and affordable complementary treatments for COVID-19: From hypothesis to pilot studies and the need for implementation. Clin Transl Allergy. 2022 Mar;12(3):e12127. DOI: 10.1002/clt2.12127

Abstract

Vaccination is a highly effective preventive measure against COVID-19. However, complementary treatments are needed to better control the disease. Fermented vegetables and spices, agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and TRPA1/V1 channels (Transient Receptor Potential Ankyrin 1 and Vanillin 1), may help in the control of COVID-19. Some preliminary clinical trials suggest that curcumin (spice) can prevent some of the COVID-19 symptoms. Before any conclusion can be drawn and these treatments recommended for COVID-19, the data warrant confirmation. In particular, the benefits of the foods need to be assessed in more patients, through research studies and large trials employing a double-blind, placebo-controlled design.