Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
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- dc.contributor.author Mingot-Castellano, M. Eva
- dc.contributor.author Álvarez Román, M. Teresa
- dc.contributor.author Fernández Fuertes, Luis Fernando
- dc.contributor.author González-López, Tomás José
- dc.contributor.author Guinea de Castro, José María
- dc.contributor.author Jarque, Isidro
- dc.contributor.author López-Fernández, M. Fernanda
- dc.contributor.author Lozano, Maria Luisa
- dc.contributor.author Sanchez Gonzalez, Blanca
- dc.contributor.author Valcárcel, David
- dc.contributor.author González Porras, José Ramón
- dc.date.accessioned 2019-11-06T08:34:25Z
- dc.date.available 2019-11-06T08:34:25Z
- dc.date.issued 2019
- dc.description.abstract BACKGROUND AND OBJECTIVE: Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and management of adult patients with ITP. MATERIALS AND METHODS: A two-round Delphi method was carried out by sending to 129 experts a 90-item questionnaire developed by 11 specialists, with a 4-point Likert scale ("never," "sometimes," "frequently," and "always") for the assessment of responses. RESULTS: Forty out of the 129 experts participated in the survey (participation rate 30.2%) and 39 completed the questionnaire (response rate 97.5%). Salient consensus points included the following: the need to indicate workup studies from a sustained platelet count < 100 x 109/L in the absence of a clear etiology; bone marrow aspiration in elderly patients with suspected ITP; beginning treatment in asymptomatic patients with a platelet count < 20 x 109/L; not exceeding 6-7 weeks of corticosteroid therapy; switching from corticosteroids to one thrombopoietin receptor agonist (TRA); switching to other TRA or other options as combinations of them with immunosuppressive drugs in case of failure; how to reduce tapering TRA; treating patients with symptomatic persistent ITP and platelet count > 20 x 109/L; and considering mucosal or severe bleeding as a basic criterion for hospital admission. CONCLUSIONS: The present consensus document provides a reference framework for the management of patients with ITP in clinical practice.
- dc.format.mimetype application/pdf
- dc.identifier.citation Mingot-Castellano ME, Álvarez-Román MT, Fernández Fuertes LF, González-López TJ, Guinea de Castro JM, Jarque I. et al. Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group. Adv Hematol. 2019 Aug 22;2019:4621416. DOI 10.1155/2019/4621416
- dc.identifier.doi http://dx.doi.org/10.1155/2019/4621416
- dc.identifier.issn 1687-9104
- dc.identifier.uri http://hdl.handle.net/10230/42732
- dc.language.iso eng
- dc.publisher Hindawi
- dc.rights Copyright © 2019 M. Eva Mingot-Castellano et al. Tis is an open access article distributed under the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/ which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other Trombocitopènia
- dc.subject.other Hematologia
- dc.title Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion