Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
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- dc.contributor.author de Mendoza, Alexca
- dc.contributor.author Suga, Hiroshica
- dc.contributor.author Permanyer, Jonca
- dc.contributor.author Irimia Martínez, Manuelca
- dc.contributor.author Ruíz Trillo, Iñakica
- dc.date.accessioned 2016-06-08T14:12:16Z
- dc.date.available 2016-06-08T14:12:16Z
- dc.date.issued 2015
- dc.description.abstract Cell-type specification through differential genome regulation is a hallmark of complex multicellularity. However, it remains unclear how this process evolved during the transition from unicellular to multicellular organisms. To address this question, we investigated transcriptional dynamics in the ichthyosporean Creolimax fragrantissima, a relative of animals that undergoes coenocytic development. We find that Creolimax utilizes dynamic regulation of alternative splicing, long inter-genic non-coding RNAs and co-regulated gene modules associated with animal multicellularity in a cell-type specific manner. Moreover, our study suggests that the different cell types of the three closest animal relatives (ichthyosporeans, filastereans and choanoflagellates) are the product of lineage-specific innovations. Additionally, a proteomic survey of the secretome reveals adaptations to a fungal-like lifestyle. In summary, the diversity of cell types among protistan relatives of animals and their complex genome regulation demonstrates that the last unicellular ancestor of animals was already capable of elaborate specification of cell types.ca
- dc.description.sponsorship Funding: European Research Council ERC-2007-StG-206883 to Alex de Mendoza, Hiroshi Suga, Iñaki Ruiz-Trillo. Ministerio de Economía y Competitividad BFU-2011-23434 to Alex de Mendoza. European Research Council ERC-2012-Co-616960 Alex de Mendoza. Japan Society for the Promotion of Science Research Activity to Hiroshi Suga. Center for Genomic Regulation Core funding to Jon Permanyer, Manuel Irimia Hiroshi Suga, Iñaki Ruiz-Trillo.
- dc.format.mimetype application/pdfca
- dc.identifier.citation de Mendoza A, Suga H, Permanyer J, Irimia M, Ruiz-Trillo I. Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals. Elife. 2015; 4: e08904. DOI 10.7554/eLife.08904ca
- dc.identifier.doi http://dx.doi.org/10.1016/10.7554/eLife.08904
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/26877
- dc.language.iso engca
- dc.publisher eLifeca
- dc.relation.ispartof Elife. 2015; 4: e08904
- dc.rights © Copyright de Mendoza et al./nThis article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.keyword Alternative splicing
- dc.subject.keyword Comparative genomics
- dc.subject.keyword Developmental biology
- dc.subject.keyword Evolutionary biology
- dc.subject.keyword Genomics
- dc.subject.keyword Lateral gene transfer
- dc.subject.keyword lincRNA
- dc.subject.keyword Multicellularity
- dc.subject.keyword Secretome
- dc.subject.keyword Stem cells
- dc.subject.other Biologia del desenvolupamentca
- dc.subject.other Cèl·lules mareca
- dc.title Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animalsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca