Stochastic modelling of HIV-1 replication in a CD4 T cell with an IFN response
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- dc.contributor.author Sazonov, Igor
- dc.contributor.author Grebennikov, Dmitry
- dc.contributor.author Savinkov, Rostislav
- dc.contributor.author Soboleva, Arina
- dc.contributor.author Pavlishin, Kirill
- dc.contributor.author Meyerhans, Andreas
- dc.contributor.author Bocharov, Gennady A.
- dc.date.accessioned 2023-05-29T06:20:35Z
- dc.date.available 2023-05-29T06:20:35Z
- dc.date.issued 2023
- dc.description.abstract A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replication inhibition by interferon-induced antiviral factors and their inactivation by the viral proteins Vpu and Vif. Both deterministic and stochastic model formulations are presented. The stochastic model was used to predict efficiency of IFN-I-induced suppression of viral replication in different initial conditions for autocrine and paracrine effects. The probability of virion excretion for various MOIs and various amounts of IFN-I was evaluated and the statistical properties of the heterogeneity of HIV-1 and IFN-I production characterised.
- dc.description.sponsorship This research was funded by the Russian Science Foundation (Grant Number 18-11-00171) and partly by the Russian Foundation for Basic Research according to the research project number 20-01-00352. A.M. is also supported by the Spanish Ministry of Science and Innovation Grant No. PID2019-106323RB-I00 AEI//10.13039/501100011033 and “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M). G.B., D.G. and R.S. were partly supported by the Moscow Center for Fundamental and Applied Mathematics (agreement with the Ministry of Education and Science of the Russian Federation No. 075-15-2022-286).
- dc.format.mimetype application/pdf
- dc.identifier.citation Sazonov I, Grebennikov D, Savinkov R, Soboleva A, Pavlishin K, Meyerhans A, Bocharov G. Stochastic modelling of HIV-1 replication in a CD4 T cell with an IFN response. Viruses. 2023 Jan 20;15(2):296. DOI: 10.3390/v15020296
- dc.identifier.doi http://dx.doi.org/10.3390/v15020296
- dc.identifier.issn 1999-4915
- dc.identifier.uri http://hdl.handle.net/10230/57002
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Viruses. 2023 Jan 20;15(2):296
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-106323RB-I00
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword HIV life cycle
- dc.subject.keyword Markov chain Monte Carlo method
- dc.subject.keyword Type I interferon (IFN-I)
- dc.subject.keyword Mathematical model
- dc.subject.keyword Sensitivity analysis
- dc.subject.keyword Stochastic processes
- dc.subject.keyword Viral dynamics
- dc.title Stochastic modelling of HIV-1 replication in a CD4 T cell with an IFN response
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion