A comprehensive view of the ß-arrestinome

Crépieux, Pascale; Poupon, Anne; Langonné Gallay, Nathalie; Reiter, Éric R.; Delgado Blanco, Javier; Schaefer, Martin H.; Bourquard, Thomas; Serrano Pubull, Luis, 1982-; Kiel, Christina

A comprehensive view of the ß-arrestinome

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dc.contributor.author Crépieux, Pascaleca
dc.contributor.author Poupon, Anneca
dc.contributor.author Langonné Gallay, Nathalieca
dc.contributor.author Reiter, Éric R.ca
dc.contributor.author Delgado Blanco, Javierca
dc.contributor.author Schaefer, Martin H.ca
dc.contributor.author Bourquard, Thomasca
dc.contributor.author Serrano Pubull, Luis, 1982-ca
dc.contributor.author Kiel, Christinaca
dc.date.accessioned 2018-05-29T10:25:12Z
dc.date.available 2018-05-29T10:25:12Z
dc.date.issued 2017
dc.description.abstract G protein-coupled receptors (GPCRs) are membrane receptors critically involved in sensing the environment and orchestrating physiological processes. As such, they transduce extracellular signals such as hormone, neurotransmitters, ions, and light into an integrated cell response. The intracellular trafficking, internalization, and signaling ability of ligand-activated GPCRs are controlled by arrestins, adaptor proteins that they interact with upon ligand binding. β-arrestins 1 and 2 in particular are now considered as hub proteins assembling multiprotein complexes to regulate receptor fate and transduce diversified cell responses. While more than 400 β-arrestin interaction partners have been identified so far, much remains to be learnt on how discrimination between so many binding partners is accomplished. Here, we gathered the interacting partners of β-arrestins through database mining and manual curation of the literature to map the β-arrestin interactome (β-arrestinome). We discussed several parameters that determine compatible (AND) or mutually exclusive (XOR) binding of β-arrestin interactors, such as structural constraints, intracellular abundance, or binding affinity.
dc.description.sponsorship This work was funded by the Agence Nationale de la Recherche GPCRnet project, by the Centre National de la Recherche Scientifique, by the Institut de la Recherche Agronomique PHASE Department, by the Région Centre, and by the European Commission (EC) Framework programme (FP) 7 project SynSignal (contract nr. 613879). LS is supported by the Spanish Ministerio de Economía y Competitividad, Plan Nacional BIO2012-39754, and the European Fund for Economic and Regional Development. LS and CK are particularly grateful for the support of the Spanish Ministry of Economy and Competitiveness, “Centro de Excelencia Severo Ochoa 2013-2017” (SEV-2012-0208).
dc.format.mimetype application/pdf
dc.identifier.citation Crépieux P, Poupon A, Langonné-Gallay N, Reiter E, Delgado J, Schaefer MH et al. A Comprehensive View of the beta-Arrestinome. Front Endocrinol (Lausanne). 2017 Mar 6;8:32. DOI: 10.3389/fendo.2017.00032
dc.identifier.doi http://dx.doi.org/10.3389/fendo.2017.00032
dc.identifier.issn 1664-2392
dc.identifier.uri http://hdl.handle.net/10230/34748
dc.language.iso eng
dc.publisher Frontiersca
dc.relation.ispartof Front Endocrinol (Lausanne). 2017 Mar 6;8:32
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/613879
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-39754
dc.rights © 2017 Crépieux, Poupon, Langonné-Gallay, Reiter, Delgado, Schaefer, Bourquard, Serrano and Kiel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword G protein-coupled receptors
dc.subject.keyword Hub proteins
dc.subject.keyword Protein/protein interaction network
dc.subject.keyword Systems biology
dc.subject.keyword β-arrestins
dc.title A comprehensive view of the ß-arrestinomeca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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