Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study

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• dc.contributor.author Peralta, Gabriela P.
• dc.contributor.author Carsin, Anne-Elie
• dc.contributor.author Antó i Boqué, Josep Maria
• dc.contributor.author Zock, Jan-Paul
• dc.contributor.author García Aymerich, Judith
• dc.date.accessioned 2020-04-30T07:22:51Z
• dc.date.available 2020-04-30T07:22:51Z
• dc.date.issued 2020
• dc.description.abstract BACKGROUND: Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS). METHODS: We included 3673 participants recruited at age 20-44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991-93, 1999-2003, 2010-14) until they were 39-67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations. RESULTS: In individuals with normal BMI, overweight and obesity at baseline, moderate (0.25-1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had -1011 mL (95% CI -1.259 to -763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<-0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline. CONCLUSION: Moderate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.
• dc.description.sponsorship The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633212. The local investigators and funding agencies for the European Community Respiratory Health Survey are reported in the online supplement. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.
• dc.format.mimetype application/pdf
• dc.identifier.citation Peralta GP, Marcon A, Carsin AE, Abramson MJ, Accordini S, Amaral AF et al. Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study. Thorax. 2020; 75(4):313-20. DOI: 10.1136/thoraxjnl-2019-213880
• dc.identifier.doi http://dx.doi.org/10.1136/thoraxjnl-2019-213880
• dc.identifier.issn 0040-6376
• dc.identifier.uri http://hdl.handle.net/10230/44372
• dc.language.iso eng
• dc.publisher BMJ Publishing Group
• dc.relation.ispartof Thorax. 2020; 75(4):313-20
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
• dc.rights © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword BMI
• dc.subject.keyword Adults
• dc.subject.keyword Epidemiology
• dc.subject.keyword Lung function
• dc.subject.keyword Obesity
• dc.subject.keyword Weight change
• dc.title Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion