Long-term risk of breast cancer after diagnosis of benign breast disease by screening mammography

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• dc.contributor.author Román, Marta
• dc.contributor.author Louro, Javier
• dc.contributor.author Posso, Margarita
• dc.contributor.author Vidal, Carmen
• dc.contributor.author Bargalló Castelló, Xavier
• dc.contributor.author Vázquez, Ivonne
• dc.contributor.author Quintana, María Jesús
• dc.contributor.author Alcántara da Silva, Rodrigo
• dc.contributor.author Saladié, Francina
• dc.contributor.author Riego, Javier del
• dc.contributor.author Peñalva, Lupe
• dc.contributor.author Sala, Maria
• dc.contributor.author Castells, Xavier
• dc.contributor.author BELE and IRIS Study Groups
• dc.date.accessioned 2022-09-22T07:02:15Z
• dc.date.available 2022-09-22T07:02:15Z
• dc.date.issued 2022
• dc.description.abstract Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.
• dc.format.mimetype application/pdf
• dc.identifier.citation Román M, Louro J, Posso M, Vidal C, Bargalló X, Vázquez I, Quintana MJ, Alcántara R, Saladié F, Del Riego J, Peñalva L, Sala M, Castells X, on behalf of the BELE and IRIS Study Groups. Long-term risk of breast cancer after diagnosis of benign breast disease by screening mammography. Int J Environ Res Public Health. 2022 Feb 24;19(5):2625. DOI: 10.3390/ijerph19052625
• dc.identifier.doi http://dx.doi.org/10.3390/ijerph19052625
• dc.identifier.issn 1661-7827
• dc.identifier.uri http://hdl.handle.net/10230/54150
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Int J Environ Res Public Health. 2022 Feb 24;19(5):2625
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Benign breast disease
• dc.subject.keyword Breast neoplasms
• dc.subject.keyword Longitudinal studies
• dc.subject.keyword Mass screening
• dc.title Long-term risk of breast cancer after diagnosis of benign breast disease by screening mammography
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion