Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients

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• dc.contributor.author Coca, Armando
• dc.contributor.author Arias Cabrales, Carlos Enrique
• dc.contributor.author Valencia, Ana Lucia
• dc.contributor.author Burballa Tàrrega, Carla, 1988-
• dc.contributor.author Bustamante-Munguira, Juan
• dc.contributor.author Redondo Pachón, María Dolores
• dc.contributor.author Acosta-Ochoa, Isabel
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Bustamante, Jesus
• dc.contributor.author Mendiluce, Alicia
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author Pérez-Sáez, María José
• dc.date.accessioned 2022-07-12T06:18:27Z
• dc.date.available 2022-07-12T06:18:27Z
• dc.date.issued 2020
• dc.description.abstract Pre-transplant prognostic scores help to optimize donor/recipient allocation and to minimize organ discard rates. Since most of these scores come from the US, direct application in non-US populations is not advisable. The Survival Benefit Estimator (SBE), built upon the Estimated Post-Transplant Survival (EPTS) and the Kidney Donor Profile Index (KDPI), has not been externally validated. We aimed to examine SBE in a cohort of Spanish kidney transplant recipients. We designed a retrospective cohort-based study of deceased-donor kidney transplants carried out in two different Spanish hospitals. Unadjusted and adjusted Cox models were applied for patient survival. Predictive models were compared using Harrell's C statistics. SBE, EPTS and KDPI were independently associated with patient survival (p ≤ 0.01 in all models). Model discrimination measured with Harrell's C statistics ranged from 0.57 (KDPI) to 0.69 (SBE) and 0.71 (EPTS). After adjustment, SBE presented similar calibration and discrimination power to that of EPTS. SBE tended to underestimate actual survival, mainly among high EPTS recipients/high KDPI donors. SBE performed acceptably well at discriminating post-transplant survival in a cohort of Spanish deceased-donor kidney transplant recipients, although its use as the main allocation guide, especially for high KDPI donors or high EPTS recipients requires further testing.
• dc.format.mimetype application/pdf
• dc.identifier.citation Coca A, Arias-Cabrales C, Valencia AL, Burballa C, Bustamante-Munguira J, Redondo-Pachón D, et al. Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients. Sci Rep. 2020 Oct 13;10(1): 17109. DOI: 10.1038/s41598-020-74295-3
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-020-74295-3
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/53717
• dc.language.iso eng
• dc.publisher Nature Research
• dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0
• dc.subject.other Ronyons--Trasplantació (Europa)
• dc.subject.other Supervivència
• dc.title Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion