Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: sex specific associations

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• dc.contributor.author Vafeiadi, Marina, 1983-
• dc.contributor.author Myridakis, Antonis
• dc.contributor.author Roumeliotaki, Theano
• dc.contributor.author Margetaki, Katerina
• dc.contributor.author Chalkiadaki, Georgia
• dc.contributor.author Dermitzaki, Eirini
• dc.contributor.author Venihaki, Maria
• dc.contributor.author Sarri, Katerina
• dc.contributor.author Vassilaki, Maria
• dc.contributor.author Leventakou, Vasiliki
• dc.contributor.author Stephanou, Euripides G.
• dc.contributor.author Kogevinas, Manolis
• dc.contributor.author Chatzi, Leda
• dc.date.accessioned 2019-05-07T07:59:58Z
• dc.date.available 2019-05-07T07:59:58Z
• dc.date.issued 2018
• dc.description.abstract Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations between phthalate exposure during gestation and childhood with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the Rhea pregnancy cohort in Crete, Greece. Seven phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)] were quantified in spot urine samples collected from mothers (1st trimester) and their children at 4 years of age. We calculated the molar sum of DEHP metabolites (MEHP, MEHHP, MEOHP). We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), and lipids at 4 and 6 years and leptin, adiponectin, and C-reactive protein at 4 years. We used generalized estimating equations to examine associations at each age and tested for interaction by sex. Child exposure to phthalate metabolites was associated with lower BMI z-scores in boys and higher BMI z-scores in girls. Each 10-fold increase in ΣDEHP was associated with a change in waist circumference of -2.6 cm (95% CI: -4.72, -0.48) in boys vs. 2.14 cm (95% CI: -0.14, 4.43) in girls (p-sex interaction = 0.003) and a change in waist-to-height ratio of -0.01 (95% CI: -0.03, 0.01) in boys vs. 0.02 (95% CI: 0.01, 0.04) in girls (p-sex interaction = 0.006). Phthalate metabolite concentrations at age 4 were negatively associated with systolic and diastolic blood pressure. MEP was associated with lower systolic BP z-scores (adj. β = -0.22; 95% CI: -0.36, -0.08) at 4 years. MnBP and MBzP were associated with lower diastolic BP z-scores (adj. β = -0.13; 95%CI: -0.23, -0.04, and adj. β = -0.11; 95% CI: -0.21, -0.01, respectively). A 10-fold increase in MiBP was associated with 4.4% higher total cholesterol levels (95% CI: 0.2, 8.7). Prenatal phthalate exposure was not consistently associated with child adiposity and cardiometabolic measures. Our findings suggest that early life phthalate exposure may affect child growth and adiposity in a sex-specific manner and depends on the timing of exposure.
• dc.description.sponsorship The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH- 2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EUFP7- HEALTH-2012 Proposal No 308333 HELIX, FP7 European Union project, No. 264357 MeDALL), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; Rhea Plus: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15).
• dc.format.mimetype application/pdf
• dc.identifier.citation Vafeiadi M, Myridakis A, Roumeliotaki T, Margetaki K, Chalkiadaki G, Dermitzaki E. et al. Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: sex specific associations. Front Public Health. 2018 Nov 27;6:327. DOI: 10.3389/fpubh.2018.00327
• dc.identifier.doi http://dx.doi.org/10.3389/fpubh.2018.00327
• dc.identifier.issn 2296-2565
• dc.identifier.uri http://hdl.handle.net/10230/37177
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Public Health. 2018 Nov 27;6:327
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/264357
• dc.rights Copyright © 2018 Vafeiadi, Myridakis, Roumeliotaki, Margetaki, Chalkiadaki, Dermitzaki, Venihaki, Sarri, Vassilaki, Leventakou, Step hanou, Kogevinas and Chatzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) a and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cardiometabolic risk
• dc.subject.keyword Children
• dc.subject.keyword Obesity
• dc.subject.keyword Phthalates
• dc.subject.keyword Pregnancy
• dc.subject.other Embaràs
• dc.subject.other Obesitat -- Infants
• dc.title Association of early life exposure to phthalates with obesity and cardiometabolic traits in childhood: sex specific associations
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion