Low-risk HPLLs/ABC score patients with splenic marginal zone lymphoma can be safely managed without treatment: Results from a prospective Spanish study

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• dc.contributor.author Muntañola, Ana
• dc.contributor.author Salar Silvestre, Antonio
• dc.contributor.author GELTAMO group
• dc.date.accessioned 2024-04-26T06:32:40Z
• dc.date.issued 2023
• dc.description.abstract The aims of our study were to analyse compliance with the 2014 GELTAMO SMZL Guidelines, in patients with splenic marginal zone lymphoma (SMZL), and to evaluate the outcome according to the HPLLs/ABC-adapted therapeutic strategy. Observational prospective multicenter study of 181 SMZL patients diagnosed between 2014 and 2020. Lymphoma-specific survival (LSS), composite event-free survival (CEFS) and response rates were assessed. 57% of the 168 patients included in the analysis followed the Guidelines. The overall response rate was higher in the rituximab chemotherapy and in the rituximab arms compared with the splenectomy arm (p < 0.001). The 5-year overall survival was 77% and the 5-year LSS of 93%. There were no differences in the 5-year LSS according to the treatment received (p = 0.68). The 5-year CEFS in the overall series was 45%, and there were significant differences between scores A and B (p = 0.036). There were no significant differences when comparing LSS and progression-free survival in patients treated with rituximab or rituximab chemotherapy at diagnosis or after observation. Our data support HPLLs/ABC score as a practical tool for the management of SMZL, observation as the best approach for patients in group A and rituximab as the best treatment for group B.
• dc.format.mimetype application/pdf
• dc.identifier.citation Muntañola A, Villalobos MT, González-Villambrosia S, Rodríguez-Salazar MJ, Jiménez-Ubieto A, Bastidas-Mora G, et al. Low-risk HPLLs/ABC score patients with splenic marginal zone lymphoma can be safely managed without treatment: Results from a prospective Spanish study. Br J Haematol. 2023 Aug;202(4):776-84. DOI: 10.1111/bjh.18912
• dc.identifier.doi http://dx.doi.org/10.1111/bjh.18912
• dc.identifier.issn 0007-1048
• dc.identifier.uri http://hdl.handle.net/10230/59910
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Br J Haematol. 2023 Aug;202(4):776-84
• dc.rights This is the peer reviewed version of the following article: Muntañola A, Villalobos MT, González-Villambrosia S, Rodríguez-Salazar MJ, Jiménez-Ubieto A, Bastidas-Mora G, et al. Low-risk HPLLs/ABC score patients with splenic marginal zone lymphoma can be safely managed without treatment: Results from a prospective Spanish study. Br J Haematol. 2023 Aug;202(4):776-84. DOI: 10.1111/bjh.18912, which has been published in final form at http://dx.doi.org/10.1111/bjh.18912. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword HPLLs/ABC score
• dc.subject.keyword SMZL Spanish Guidelines
• dc.subject.keyword Splenic marginal zone lymphoma (SMZL)
• dc.subject.keyword Therapeutic management
• dc.title Low-risk HPLLs/ABC score patients with splenic marginal zone lymphoma can be safely managed without treatment: Results from a prospective Spanish study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion