Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

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  • dc.contributor.author Olalde Marquínez, Íñigo, 1987-
  • dc.contributor.author Sánchez Quinto, Federico A, 1985-
  • dc.contributor.author Santpere Baró, Gabriel, 1981-
  • dc.contributor.author Rodríguez Pérez, Juan Antonio, 1985-
  • dc.contributor.author Quilez Oliete, Javier
  • dc.contributor.author Ramírez, Oscar
  • dc.contributor.author Marigorta, Urko M.
  • dc.contributor.author Fernández Callejo, Marcos
  • dc.contributor.author Marquès i Bonet, Tomàs, 1975-
  • dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
  • dc.contributor.author Lalueza Fox, Carles, 1965-
  • dc.date.accessioned 2019-02-26T12:22:13Z
  • dc.date.available 2019-02-26T12:22:13Z
  • dc.date.issued 2014
  • dc.description.abstract Ancient genomic sequences have started to reveal the origin and the demographic impact of farmers from the Neolithic period spreading into Europe. The adoption of farming, stock breeding and sedentary societies during the Neolithic may have resulted in adaptive changes in genes associated with immunity and diet. However, the limited data available from earlier hunter-gatherers preclude an understanding of the selective processes associated with this crucial transition to agriculture in recent human evolution. Here we sequence an approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, to retrieve a complete pre-agricultural European human genome. Analysis of this genome in the context of other ancient samples suggests the existence of a common ancient genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic. The La Braña individual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times. Moreover, we provide evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
  • dc.description.sponsorship The POPRES data were obtained from dbGaP (accession number # 2038). The Danish National Research Foundation, ERC Starting Grant (260372) to TM-B, and (310372) to MGN, FEDER and Spanish Government Grants BFU2009-13409-C02-02, BFU2012-38236 to AN, BFU2011-28549 to TM-B, BFU2012-34157 to CL-F, ERC (Marie Cure Actions) to MEA, NIH NRSA postdoctoral fellowship (F32GM106656) to CWKC, NIH (R01-HG007089) to JN, NSF postdoctoral fellowship (DBI-1103639) to MDG
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CW, DeGiorgio M et al. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature. 2014 Mar 13; 507(7491): 225-8. DOI: 10.1038/nature12960
  • dc.identifier.doi http://dx.doi.org/10.1038/nature12960
  • dc.identifier.issn 0028-0836
  • dc.identifier.uri http://hdl.handle.net/10230/36679
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Nature. 2014 Mar 13;507(7491):225-8
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260372
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310372
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-13409-C02-02
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-38236
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28549
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-34157
  • dc.rights © Springer Nature Publishing AG. Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CW, DeGiorgio M et al. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature. 2014 Mar 13; 507(7491): 225-8. http://dx.doi.org/10.1038/nature12960
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Al·lel
  • dc.subject.other Genealogia
  • dc.subject.other Fòssils
  • dc.subject.other Immunogenètica
  • dc.subject.other Color de la pell humana -- Genètica
  • dc.title Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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