Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells

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• dc.contributor.author Miguel, Cristina de
• dc.contributor.author Cruz, Josefa
• dc.contributor.author Martín, David
• dc.contributor.author Franch i Marro, Xavier
• dc.date.accessioned 2023-01-24T07:17:22Z
• dc.date.available 2023-01-24T07:17:22Z
• dc.date.issued 2019
• dc.description Includes supplemental material file: supplementary figures
• dc.description.abstract Adult progenitor cells activation is a key event in the formation of adult organs. In Drosophila, formation of abdominal adult trachea depends on the specific activation of tracheal adult progenitors (tracheoblasts) at the Tr4 and Tr5 spiracular branches. Proliferation of these tracheoblasts generates a pool of tracheal cells that migrate toward the posterior part of the trachea by the activation of the branchless/fibroblast growth factor (Bnl/FGF) signaling to form the abdominal adult trachea. Here, we show that, in addition to migration, Bnl/FGF signaling, mediated by the transcription factor Pointed, is also required for tracheoblast proliferation. This tracheoblast activation relies on the expression of the FGF ligand bnl in their nearby branches. Finally, we show that, in the absence of the transcription factor Cut (Ct), Bnl/FGF signaling induces endoreplication of tracheoblasts partially by promoting fizzy-related expression. Altogether, our results suggest a dual role of Bnl/FGF signaling in tracheoblasts, inducing both proliferation and endoreplication, depending on the presence or absence of the transcription factor Ct, respectively.
• dc.description.sponsorship Support for this research was provided by the Spanish Ministerio de Economía, Industria y Competitividad (MINECO) and Agencia Estatal de Investigación (AEI) (BFU2009-08748, CGL2014-55786-P, and PGC2018-098427-B-I00 to D.M. and X.F.-M.) and by the Catalan Government Generalitat de Catalunya (2014 SGR 619 to D.M. and X.F-M.). The research has also benefited from Fondo Europeo de Desarrollo Regional (FEDER) funds. J.C. was supported by the CGL2014-55786-P grant from the Spanish MINECO, and C.d.M. was supported by FPI from the Spanish MINECO.
• dc.format.mimetype application/pdf
• dc.identifier.citation De Miguel C, Cruz J, Martín D, Franch-Marro X. Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells. Journal of Molecular Cell Biology. 2019 Jun;12(1):32-41. DOI: 10.1093/jmcb/mjz055
• dc.identifier.doi http://dx.doi.org/10.1093/jmcb/mjz055
• dc.identifier.issn 1674-2788
• dc.identifier.uri http://hdl.handle.net/10230/55407
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Journal of Molecular Cell Biology. 2019 Jun;12(1):32-41
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-08748
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CGL2014-55786-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-098427-B-I00
• dc.rights © The Author(s) (2019). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword FGF
• dc.subject.keyword Fzr
• dc.subject.keyword Pnt
• dc.subject.keyword Adult progenitors
• dc.subject.keyword Cut
• dc.subject.keyword Endoreplication
• dc.subject.keyword Proliferation
• dc.subject.keyword Trachea
• dc.title Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion