High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years-single institution experience

Membrive Conejo, Ismael; Pera Cegarra, Óscar; Foro Arnalot, Palmira; Reig Castillejo, Anna; Rodríguez de Dios, Núria; Sanz Latiesas, Javier, 1967-; Deza Vargas, Luis Gustavo; Quera Jordana, Jaume; Fernández-Velilla Cepria, Enric; Martínez Moñino, Álvaro; Liu Cheng, F.; Algara López, Manuel-Ignacio

doi:http://dx.doi.org/10.1007/s12094-021-02718-2

High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years-single institution experience

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Membrive Conejo I, Pera Cegarra O, Foro Arnalot P, Reig Castillejo A, Rodríguez de Dios N, Sanz Latiesas X, Deza G, Quera Jordana J, Fernandez-Velilla Cepria E, Martínez Moñino A, Liu Cheng F, Algara López M. High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years-single institution experience. Clin Transl Oncol. 2022;24(3):578-85. DOI: 10.1007/s12094-021-02718-2

Abstract

Purpose: Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. Methods/patients: We planned the treatment using two computed tomography (CT) scans: the first to delineate the lesion and the second after placing the thermoplastic mold. Fusing the two CT images enables planning of the target volume and pinpointing, where the catheters are in the mold. Results: Seventy patients received plesiotherapy, either exclusively or following excision in patients with risk factors for recurrence. Those receiving plesiotherapy alone showed a complete response rate of 95.8%, and recurrences occurred in 5.7% at a mean follow-up of 96.2 months. Chronic toxicity appeared in 26.6% of patients, but severity was limited to grade 1 or 2. Conclusions: High-dose-rate brachytherapy with customized molds yields a high rate of complete response, with long-term recurrence rates in line with similar studies and an acceptable toxicity rate.