Therapeutic outcomes and survival analysis of Extramammary Paget's disease: A multicentre retrospective study of 249 patients

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  • dc.contributor.author Escolà, Helena
  • dc.contributor.author Leal, Lorena
  • dc.contributor.author Pujol Vallverdú, Ramon Maria
  • dc.contributor.author Deza Vargas, Luis Gustavo
  • dc.date.accessioned 2024-05-27T06:20:38Z
  • dc.date.issued 2024
  • dc.description.abstract Background: Evidence regarding long-term therapeutic outcomes and disease-specific survival (DSS) in Extramammary Paget's disease (EMPD) is limited. Objectives: To assess the DSS and outcomes of surgical and nonsurgical therapeutic modalities in a large cohort of EMPD patients. Methods: Retrospective chart review of EMPD patients from 20 Spanish tertiary care hospitals. Results: Data on 249 patients with a median follow-up of 60 months were analyzed. The estimated 5-, 10-, and 15-year DSS was 95.9%, 92.9%, and 88.5%, respectively. A significantly lower DSS was observed in patients showing deep dermal invasion (≥1 mm) or metastatic disease (P < .05). A ≥50% reduction in EMPD lesion size was achieved in 100% and 75.3% of patients treated with surgery and topical therapies, respectively. Tumor-free resection margins were obtained in 42.4% of the patients after wide local excision (WLE). The 5-year recurrence-free survival after Mohs micrographic surgery (MMS), WLE with tumor-free margins, WLE with positive margins, radiotherapy, and topical treatments was 63.0%, 51.4%, 20.4%, 30.1%, and 20.8%, respectively. Limitations: Retrospective design. Conclusions: EMPD is usually a chronic condition with favorable prognosis. MMS represents the therapeutic alternative with the greatest efficacy for the disease. Recurrence rates in patients with positive margins after WLE are similar to the ones observed in patients treated with topical agents.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Escolà H, Llombart B, Escolà-Rodríguez A, Barchino-Ortiz L, Marcoval J, Alcaraz I, et al. Therapeutic outcomes and survival analysis of Extramammary Paget's disease: A multicentre retrospective study of 249 patients. J Am Acad Dermatol. 2024 Jan;90(1):66-73. DOI: 10.1016/j.jaad.2023.08.088
  • dc.identifier.doi http://dx.doi.org/10.1016/j.jaad.2023.08.088
  • dc.identifier.issn 0190-9622
  • dc.identifier.uri http://hdl.handle.net/10230/60242
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof J Am Acad Dermatol. 2024 Jan;90(1):66-73
  • dc.rights © Elsevier http://dx.doi.org/10.1016/j.jaad.2023.08.088
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Extramammary Paget's disease
  • dc.subject.keyword Mohs micrographic surgery
  • dc.subject.keyword Imiquimod
  • dc.subject.keyword Local recurrence
  • dc.subject.keyword Margin status
  • dc.subject.keyword Radiotherapy
  • dc.title Therapeutic outcomes and survival analysis of Extramammary Paget's disease: A multicentre retrospective study of 249 patients
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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