Snail1: a transcriptional factor controlled at multiple levels

Baulida i Estadella, Josep, 1965-; Díaz Cortés, Víctor Manuel, 1956-; García de Herreros, Antonio

doi:http://dx.doi.org/10.3390/jcm8060757

Snail1: a transcriptional factor controlled at multiple levels

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Baulida J, Díaz VM, Herreros AG. Snail1: A Transcriptional Factor Controlled at Multiple Levels. J Clin Med. 2019 May 28;8(6):757. DOI: 10.3390/jcm8060757

Abstract

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator.