Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
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- dc.contributor.author Balcells Nadal, Cristina
- dc.contributor.author Xu, Yitao
- dc.contributor.author Gil Solsona, Rubén
- dc.contributor.author Maitre, Léa
- dc.contributor.author Gago Ferrero, Pablo
- dc.contributor.author Keun, Hector C.
- dc.date.accessioned 2024-06-14T06:42:50Z
- dc.date.available 2024-06-14T06:42:50Z
- dc.date.issued 2024
- dc.description.abstract The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteome, and the metabolome. The chemical exposome, deeply intertwined with the metabolome, includes all small molecules originating from diet as well as pharmaceuticals, personal care and consumer products, or pollutants in air and water. The set of techniques to interrogate these exposures, primarily mass spectrometry and nuclear magnetic resonance spectroscopy, are also extensively used in metabolomics. Recent advances in untargeted metabolomics using high resolution mass spectrometry have paved the way for the development of methods able to provide in depth characterisation of both the internal chemical exposome and the endogenous metabolome simultaneously. Herein we review the available tools, databases, and workflows currently available for such work, and discuss how these can bridge the gap between the study of the metabolome and the exposome.
- dc.description.sponsorship CB, LM and HCK received funding from European Union's Horizon 2020 research and innovation programme under grant agreement no. 874583 [ATHLETE]. YX is supported by the President's PhD Scholarship from Imperial College London.
- dc.format.mimetype application/pdf
- dc.identifier.citation Balcells C, Xu Y, Gil-Solsona R, Maitre L, Gago-Ferrero P, Keun HC. Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome. Curr Opin Chem Biol. 2024 Feb;78:102407. DOI: 10.1016/j.cbpa.2023.102407
- dc.identifier.doi http://dx.doi.org/10.1016/j.cbpa.2023.102407
- dc.identifier.issn 1367-5931
- dc.identifier.uri http://hdl.handle.net/10230/60467
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Curr Opin Chem Biol. 2024 Feb;78:102407
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
- dc.rights © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Chemical exposome
- dc.subject.keyword Exposomics
- dc.subject.keyword HRMS
- dc.subject.keyword Mass spectrometry
- dc.subject.keyword Metabolomics
- dc.title Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion