Pluripotent stem cell models of early mammalian development
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- dc.contributor.author Baillie-Benson, Peter
- dc.contributor.author Moris, Naomi
- dc.contributor.author Martínez Arias, Alfonso
- dc.date.accessioned 2023-04-25T06:14:33Z
- dc.date.available 2023-04-25T06:14:33Z
- dc.date.issued 2020
- dc.description.abstract Pluripotent stem cells derived from the early mammalian embryo offer a convenient model system for studying cell fate decisions in embryogenesis. The last 10 years have seen a boom in the popularity of two-dimensional micropatterns and three-dimensional stem cell culture systems as a way to recreate the architecture and interactions of particular cell populations during development. These methods enable the controlled exploration of cellular organization and patterning during development, using cell lines instead of embryos. They have established a new class of in vitro model system for pre-implantation and peri-implantation embryogenesis, ranging from models of the blastocyst stage, through gastrulation and toward early organogenesis. This review aims to set these systems in context and to highlight the strengths and suitability of each approach in modelling early mammalian development.
- dc.description.sponsorship This work was supported by the European Research Council (advanced grant to AMA, number 834580) and the Leverhulme Trust (RPG-2018-356). NM holds the Constance Work Junior Research Fellowship at Newnham College, Cambridge.
- dc.format.mimetype application/pdf
- dc.identifier.citation Baillie-Benson P, Moris N, Martinez Arias A. Pluripotent stem cell models of early mammalian development. Curr Opin Cell Biol. 2020 Oct;66:89-96. DOI: 10.1016/j.ceb.2020.05.010
- dc.identifier.doi http://dx.doi.org/10.1016/j.ceb.2020.05.010
- dc.identifier.issn 0955-0674
- dc.identifier.uri http://hdl.handle.net/10230/56560
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Curr Opin Cell Biol. 2020 Oct;66:89-96
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/834580
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.ceb.2020.05.010
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Blastoid
- dc.subject.keyword Development
- dc.subject.keyword ETX-Embryo
- dc.subject.keyword Embryo
- dc.subject.keyword Embryoid body
- dc.subject.keyword Gastruloid
- dc.subject.keyword Micropattern
- dc.subject.keyword Organoid
- dc.subject.keyword Stem cell
- dc.title Pluripotent stem cell models of early mammalian development
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion