Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control study

Posso, Margarita; Corominas Torres, Josep Maria; Serrano, Laia; Román, Marta; Torá Rocamora, Isabel, 1979-; Domingo, Laia; Romero, Anabel; Quintana, María Jesús; Vernet-Tomás, Maria; Baré, Marisa; Vidal, Carmen; Sánchez, Mar; Saladié, Francina; Natal, Carmen; Ferrer, Joana; Servitja Tormo, Sonia; Sala, Maria; Castells, Xavier; BELE Study Group

Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control study

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dc.contributor.author Posso, Margaritaca
dc.contributor.author Corominas Torres, Josep Mariaca
dc.contributor.author Serrano, Laiaca
dc.contributor.author Román, Martaca
dc.contributor.author Torá Rocamora, Isabel, 1979-ca
dc.contributor.author Domingo, Laiaca
dc.contributor.author Romero, Anabelca
dc.contributor.author Quintana, María Jesúsca
dc.contributor.author Vernet-Tomás, Mariaca
dc.contributor.author Baré, Marisaca
dc.contributor.author Vidal, Carmenca
dc.contributor.author Sánchez, Marca
dc.contributor.author Saladié, Francinaca
dc.contributor.author Natal, Carmenca
dc.contributor.author Ferrer, Joanaca
dc.contributor.author Servitja Tormo, Soniaca
dc.contributor.author Sala, Mariaca
dc.contributor.author Castells, Xavierca
dc.contributor.author BELE Study Groupca
dc.date.accessioned 2018-05-02T07:05:02Z
dc.date.available 2018-05-02T07:05:02Z
dc.date.issued 2017
dc.description.abstract Women with benign breast diseases (BBD) have a high risk of breast cancer. However, no biomarkers have been clearly established to predict cancer in these women. Our aim was to explore whether estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression stratify risk of breast cancer in screened women with BBD. We conducted a nested case-control study. Women with breast cancer and prior BBDs (86 cases) were matched to women with prior BBDs who were free from breast cancer (172 controls). The matching factors were age at BBD diagnosis, type of BBD, and follow-up time since BBD diagnosis. ER, PR, and Ki67 expression were obtained from BBDs' specimens. Conditional logistic regression was used to estimate odds ratios (ORs), and 95% confidence intervals (CIs) of breast cancer risk according to ER, PR, and Ki67 expression. Women with >90% of ER expression had a higher risk of breast cancer (OR = 2.63; 95% CI: 1.26-5.51) than women with ≤70% of ER expression. Similarly, women with >80% of PR expression had a higher risk of breast cancer (OR = 2.22; 95% CI: 1.15-4.27) than women with ≤40% of PR expression. Women with proliferative disease and ≥1% of Ki67 expression had a nonsignificantly increased risk of breast cancer (OR = 1.16; 95% CI: 0.46-2.90) than women with <1% of Ki67 expression. A high expression of ER and PR in BBD is associated with an increased risk of subsequent breast cancer. In proliferative disease, high Ki67 expression may also have an increased risk. This information is helpful to better characterize BBD and is one more step toward personalizing the clinical management of these women.
dc.format.mimetype application/pdf
dc.identifier.citation Posso M, Corominas JM, Serrano L, Román M, Torá-Rocamora I, Domingo L. et al. Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control study. Cancer Med. 2017 Jun;6(6):1482-1489. DOI: 10.1002/cam4.1080
dc.identifier.doi http://dx.doi.org/10.1002/cam4.1080
dc.identifier.issn 2045-7634
dc.identifier.uri http://hdl.handle.net/10230/34523
dc.language.iso eng
dc.publisher Wileyca
dc.relation.ispartof Cancer Medicine. 2017 Jun;6(6):1482-9
dc.rights copyright © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Benign breast disease
dc.subject.keyword Biomarkers
dc.subject.keyword Breast cancer
dc.subject.keyword Early detection
dc.subject.keyword Screening
dc.subject.other Mama -- Càncer
dc.subject.other Marcadors bioquímics
dc.title Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control studyca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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