Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis

Czachorowski, Maciej J; Amaral, André F.S.; Montes-Moreno, Santiago; Lloreta, Josep, 1958-; Carrato, Alfredo; Tardón, Adonina; Morente, Manuel M; Kogevinas, Manolis; Real, Francisco X.; Malats i Riera, Núria

Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis

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dc.contributor.author Czachorowski, Maciej Jca
dc.contributor.author Amaral, André F.S.ca
dc.contributor.author Montes-Moreno, Santiagoca
dc.contributor.author Lloreta, Josep, 1958-ca
dc.contributor.author Carrato, Alfredoca
dc.contributor.author Tardón, Adoninaca
dc.contributor.author Morente, Manuel Mca
dc.contributor.author Kogevinas, Manolisca
dc.contributor.author Real, Francisco X.ca
dc.contributor.author Malats i Riera, Núriaca
dc.date.accessioned 2015-05-12T09:47:07Z
dc.date.available 2015-05-12T09:47:07Z
dc.date.issued 2012ca
dc.description.abstract Aberrant overexpression of cyclooxygenase-2 (COX2) is observed in urothelial carcinoma of the bladder (UCB). Studies evaluating COX2 as a prognostic marker in UCB report contradictory results. We determined the prognostic potential of COX2 expression in UCB and quantitatively summarize the results with those of the literature through a meta-analysis. Newly diagnosed UCB patients recruited between 1998–2001 in 18 Spanish hospitals were prospectively included in the study and followed-up (median, 70.7 months). Diagnostic slides were reviewed and uniformly classified by expert pathologists. Clinical data was retrieved from hospital charts. Tissue microarrays containing non-muscle invasive (n = 557) and muscle invasive (n = 216) tumours were analyzed by immunohistochemistry using quantitative image analysis. Expression was evaluated in Cox regression models to assess the risk of recurrence, progression and disease-specific mortality. Meta-hazard ratios were estimated using our results and those from 11 additional evaluable studies. COX2 expression was observed in 38% (211/557) of non-muscle invasive and 63% (137/216) of muscle invasive tumors. Expression was associated with advanced pathological stage and grade (p<0.0001). In the univariable analyses, COX2 expression - as a categorical variable - was not associated with any of the outcomes analyzed. As a continuous variable, a weak association with recurrence in non-muscle invasive tumors was observed (p-value = 0.048). In the multivariable analyses, COX2 expression did not independently predict any of the considered outcomes. The meta-analysis confirmed these results. We did not find evidence that COX2 expression is an independent prognostic marker of recurrence, progression or survival in patients with UCB.en
dc.description.sponsorship The work was partially supported by the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Ministry of Science and Innovation, Spain (G03/174, 00/0745, PI051436, PI061614 and G03/174); Red Temática de Investigación Cooperativa en Cáncer- RD06/0020-RTICC; Consolider ONCOBIO; EU-FP6-STREP-37739-DRoP-ToP; EU-FP7-HEALTH-F2-2008-201663-UROMOL; EU-FP7-HEALTH-F2-2008-201333-DECanBio; USA-NIH-RO1-CA089715; and a PhD fellowship awarded to MJC from the ‘‘la Caixa’’ foundation, Spain, and a postdoctoral fellowship awarded to AFSA from the Fundación Científica de la AECCen
dc.format.mimetype application/pdfca
dc.identifier.citation Czachorowski MJ, Amaral AFS, Montes-Moreno S, Lloreta J, Carrato A, Tardón A et al. Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis. PLoS ONE. 2012;7(9):e45025. DOI: 10.1371/journal.pone.0045025ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0045025
dc.identifier.issn 1932-6203ca
dc.identifier.uri http://hdl.handle.net/10230/23558
dc.language.iso engca
dc.publisher Public Library of Science (PLoS)ca
dc.relation.ispartof PLoS ONE. 2012;7(9):e45025
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/37739ca
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201663
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201333
dc.rights © 2012 Czachorowski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Bufeta -- Càncer -- Etiologia -- Diferències entre sexesca
dc.title Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysisen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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