Acid-base safety during the course of a very low-calorie-ketogenic diet
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- dc.contributor.author Gomez-Arbelaez, Diegoca
- dc.contributor.author Crujeiras, Ana B.ca
- dc.contributor.author Castro, Ana I.ca
- dc.contributor.author Goday Arno, Albertoca
- dc.contributor.author Mas-Lorenzo, Antonioca
- dc.contributor.author Bellon, Anaca
- dc.contributor.author Tejera, Cristinaca
- dc.contributor.author Bellido, Diegoca
- dc.contributor.author Galban, Cristobalca
- dc.contributor.author Sajoux, Ignacioca
- dc.contributor.author Lopez-Jaramillo, Patricioca
- dc.contributor.author Casanueva, Felipe F.ca
- dc.date.accessioned 2018-05-15T07:11:06Z
- dc.date.available 2018-05-15T07:11:06Z
- dc.date.issued 2017
- dc.description.abstract BACKGROUND AND AIMS: Very low-calorie ketogenic (VLCK) diets have been consistently shown to be an effective obesity treatment, but the current evidence for its acid-base safety is limited. The aim of the current work was to evaluate the acid-base status of obese patients during the course of a VLCK diet. METHOD: Twenty obese participants undertook a VLCK diet for 4 months. Anthropometric and biochemical parameters, and venous blood gases were obtained on four subsequent visits: visit C-1 (baseline); visit C-2, (1-2 months); maximum ketosis; visit C-3 (2-3 months), ketosis declining; and visit C-4 at 4 months, no ketosis. Results were compared with 51 patients that had an episode of diabetic ketoacidosis as well as with a group that underwent a similar VLCK diet in real life conditions of treatment. RESULTS: Visit C1 blood pH (7.37 ± 0.03); plasma bicarbonate (24.7 ± 2.5 mmol/l); plasma glucose (96.0 ± 11.7 mg/l) as well as anion gap or osmolarity were not statistically modified at four months after a total weight reduction of 20.7 kg in average and were within the normal range throughout the study. Even at the point of maximum ketosis all variables measured were always far from the cut-off points established to diabetic ketoacidosis. CONCLUSION: During the course of a VLCK diet there were no clinically or statistically significant changes in glucose, blood pH, anion gap and plasma bicarbonate. Hence the VLCK diet can be considered as a safe nutritional intervention for the treatment of obesity in terms of acid-base equilibrium.
- dc.format.mimetype application/pdf
- dc.identifier.citation Gomez-Arbelaez D, Crujeiras AB, Castro AI, Goday A, Mas-Lorenzo A, Bellon A.et al. Acid-base safety during the course of a very low-calorie-ketogenic diet. Endocrine. 2017 Oct;58(1):81-90. DOI: 10.1007/s12020-017-1405-3
- dc.identifier.doi http://dx.doi.org/10.1007/s12020-017-1405-3
- dc.identifier.issn 1355-008X
- dc.identifier.uri http://hdl.handle.net/10230/34629
- dc.language.iso eng
- dc.publisher Elsevierca
- dc.relation.ispartof Endocrine. 2017 Oct;58(1):81-90
- dc.rights Copyright © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Acidosis
- dc.subject.keyword Acid–base safety
- dc.subject.keyword Ketogenic diet
- dc.subject.keyword Ketosis
- dc.subject.keyword Obesity
- dc.subject.keyword Very low-energy diet
- dc.subject.other Dieta hipocalòrica
- dc.subject.other Acidosi
- dc.title Acid-base safety during the course of a very low-calorie-ketogenic dietca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion