Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5
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- dc.contributor.author Grau-Bové, Carme
- dc.contributor.author Grau Bové, Xavier
- dc.contributor.author Terra, Ximena
- dc.contributor.author Garcia Vallvé, Santiago
- dc.contributor.author Rodríguez-Gallego, Esther
- dc.contributor.author Beltran-Debón, Raúl
- dc.contributor.author Blay, M. Teresa
- dc.contributor.author Ardévol, Anna
- dc.contributor.author Pinent, Montserrat
- dc.date.accessioned 2022-04-04T06:30:59Z
- dc.date.available 2022-04-04T06:30:59Z
- dc.date.issued 2022
- dc.description.abstract Bitterness is perceived in humans by 25 subtypes of bitter taste receptors (hTAS2R) that range from broadly tuned to more narrowly tuned receptors. hTAS2R5 is one of the most narrowly tuned bitter taste receptors in humans. In this study, we review the literature on this receptor and show there is no consensus about its role. We then compare the possible role of hTAS2R5 with that of the proteins of the TAS2R family in rat, mouse, and pig. A phylogenetic tree of all mammalian TAS2R domain-containing proteins showed that human hTAS2R5 has no ortholog in pig, mouse, or rat genomes. By comparing the agonists that are common to hTAS2R5 and other members of the family, we observed that hTAS2R39 is the receptor that shares most agonists with hTAS2R5. In mouse, some of these agonists activate mTas2r105 and mTas2r144, which are distant paralogs of hTAS2R5. mTas2r144 seems to be the receptor that is most similar to hTAS2R5 because they are both activated by the same agonists and have affinities in the same range of values. Then, we can conclude that hTAS2R5 has a unique functional specificity in humans as it is activated by selective agonists and that its closest functional homolog in mouse is the phylogenetically distant mTas2r144.
- dc.description.sponsorship This research was funded by MCIN/AEI/10.13039/501100011033/FEDER “Una manera de hacer Europa”, grant number AGL2017-83477-R, C. Grau-Bové received a doctoral research grant from the Martí Franqués program of the Universitat Rovira i Virgili. M. Pinent and X. Terra are Serra Húnter fellows. We would like to express our thanks to Judith Pérez for her contribution to this work.
- dc.format.mimetype application/pdf
- dc.identifier.citation Grau-Bové C, Grau-Bové X, Terra X, Garcia-Vallve S, Rodríguez-Gallego E, Beltran-Debón R, Blay MT, Ardévol A, Pinent M. Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5. FASEB J. 2022 Mar;36(3):e22175. DOI: 10.1096/fj.202101128RR
- dc.identifier.doi http://dx.doi.org/10.1096/fj.202101128RR
- dc.identifier.issn 0892-6638
- dc.identifier.uri http://hdl.handle.net/10230/52817
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof FASEB J. 2022 Mar;36(3):e22175
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/AGL2017-83477-R
- dc.rights © 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Agonist assays
- dc.subject.keyword Bitter taste receptor
- dc.subject.keyword hTAS2R5
- dc.title Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion