Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study.

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  • dc.contributor.author Garcia-Arellano, Anaca
  • dc.contributor.author Martínez-González, Miguel Ángel, 1957-ca
  • dc.contributor.author Schröder, Helmut, 1958-ca
  • dc.contributor.author PREDIMED investigatorsca
  • dc.date.accessioned 2015-11-16T08:27:43Z
  • dc.date.available 2015-11-16T08:27:43Z
  • dc.date.issued 2015
  • dc.description.abstract Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevención con Dieta Mediterránea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HR(quartile2) = 1.42 (95%CI = 0.97-2.09); HR(quartile3) = 1.85 (1.27-2.71); and HR(quartile4) = 1.73 (1.15-2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06-1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events.ca
  • dc.description.sponsorship This research was supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140, to RE; RTIC RD 06/0045, to MAM-G) and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), the Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (Proyecto de Investigación (PI) 04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462), the Ministerio de Ciencia e Innovación (Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083- C3-1-R), the Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, the Generalitat Valenciana (Generalitat Valenciana Ayuda Complementatia (GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151), Conselleria de Sanitat y AP; Atención Primaria (CS) 2010-AP-111, and CS2011-AP-042), Regional Government of Navarra (P27/2011), and Centre Català de la Nutrició de l'Institut d'Estudis Catalans. ET is supported by a Rio Hortega post-residency fellow of the Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Spanish Government.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Garcia-Arellano A, Ramallal R, Ruiz-Canela M, Salas-Salvadó J, Corella D, Shivappa N. et al. Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study. Nutrients. 2015 May 29;7(6):4124-38. doi: 10.3390/nu7064124.ca
  • dc.identifier.doi http://dx.doi.org/10.3390/nu7064124
  • dc.identifier.issn 2072-6643
  • dc.identifier.uri http://hdl.handle.net/10230/25089
  • dc.language.iso engca
  • dc.publisher MDPI Publishingca
  • dc.relation.ispartof Nutrients. 2015 May 29;7(6):4124-38
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2013-49083
  • dc.rights © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Sistema cardiovascular -- Malaltiesca
  • dc.subject.other Inflamacióca
  • dc.title Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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