Experimentally induced intrauterine growth restriction in rabbits leads to differential remodelling of left versus right ventricular myocardial microstructure

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• dc.contributor.author Schipke, Julia
• dc.contributor.author Gonzalez-Tendero, Anna
• dc.contributor.author Cornejo, Lidia
• dc.contributor.author Willführ, Alper
• dc.contributor.author Bijnens, Bart
• dc.contributor.author Crispi Brillas, Fàtima
• dc.contributor.author Mühlfeld, Christian
• dc.contributor.author Gratacós Solsona, Eduard
• dc.date.accessioned 2019-03-28T08:32:07Z
• dc.date.available 2019-03-28T08:32:07Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND: Intrauterine growth restriction (IUGR) affects up to 7-10% of pregnancies and is associated with fetal cardiac remodelling and dysfunction in utero together with increased risk of cardiovascular disease in adulthood. Experimental data concerning the effects of IUGR on cardiomyocyte and microvascularization anatomy are inconsistent and it is unknown whether both ventricles are similarly susceptible to in utero undersupply. METHODS AND RESULTS: IUGR was induced in pregnant New Zealand rabbits at 25 days of gestation by selective ligation of the uteroplacental vessels. Fetal echocardiography showed systolic and diastolic dysfunction of both ventricles in response to IUGR. Birth weight and heart weight were significantly reduced in the IUGR offspring. Design-based stereology revealed a decrease in cardiomyocyte number in both ventricles which was only in the left ventricle accompanied by a significantly higher cardiomyocyte mean volume. The proportion of mono- and bi-nucleated cardiomyocytes was unaltered between the groups indicating a similar maturation status. The number of cardiac capillaries in IUGR offspring was significantly diminished in left but not in right ventricles. CONCLUSIONS: We conclude that left and right ventricles are differently affected by placental insufficiency. While cardiomyocyte numbers are diminished in both ventricles, hypertrophic remodelling of cardiomyocytes and alterations in microvascularization is rather a left ventricular adaptation to IUGR. These unequal structural changes in response to IUGR may be related to developmental differences of the left and right ventricle.
• dc.description.sponsorship This work was partially supported by grants from Instituto de Salud Carlos III (grants number PI14/00226 and PI15/00130) cofinanced by the Fondo Europeo de Desarrollo Regional de la Unión Europea “Una manera de hacer Europa” (FEDER), and AGAUR 2014 SGR grant nº 928. The research leading to these results has received funding from “la Caixa” Foundation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Schipke J, Gonzalez-Tendero A, Cornejo L, Willführ A, Bijnens B, Crispi F, Mühlfeld C, Gratacós E. Experimentally induced intrauterine growth restriction in rabbits leads to differential remodelling of left versus right ventricular myocardial microstructure. Histochem Cell Biol. 2017 Nov;148(5):557-6. DOI: 10.1007/s00418-017-1587-z
• dc.identifier.doi http://dx.doi.org/10.1007/s00418-017-1587-z
• dc.identifier.issn 0948-6143
• dc.identifier.uri http://hdl.handle.net/10230/36997
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Histochemistry and Cell Biology. 2017 Nov;148(5):557-6.
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00418-017-1587-z
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cardiomyocyte number
• dc.subject.keyword IUGR
• dc.subject.keyword Microvascularization
• dc.subject.keyword Ventricle-related
• dc.title Experimentally induced intrauterine growth restriction in rabbits leads to differential remodelling of left versus right ventricular myocardial microstructure
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion