Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study
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- dc.contributor.author Dierssen Sotos, Trinidadca
- dc.contributor.author Andreu García, Montserratca
- dc.contributor.author Castaño Vinyals, Gemmaca
- dc.contributor.author Kogevinas, Manolisca
- dc.contributor.author Llorca, Javierca
- dc.date.accessioned 2018-02-27T08:38:13Z
- dc.date.issued 2017
- dc.description.abstract The potential protective effect of renin-angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this association, we conducted a case-control study with 2165 cases of colorectal cancer, diagnosed between 2007 and 2012, and 3912 population controls frequency matched (by age, sex and region) from the Spanish multicenter case-control study MCC-Spain. We found a significant protective effect of the angiotensin-converting enzyme Inhibitors (ACEIs) against CRC, limited to the under-65years group (OR=0.65 95%CI (0.48-0.89)) and to a lesser degree to men (OR=0.81 95%CI (0.66-0.99). In contrast, the angiotensin receptor blockers (ARBs) did not show a significant effect. Regarding the duration of use, a greater protection was observed in men as the length of consumption increases. In contrast, in the under-65 stratum, the strongest association was found in short-term treatments. Finally, by analyzing ACEIs effect by colon subsite, we found no differences, except for under 65years old, where the maximum protection was seen in the proximal intestine, descending in the distal and rectum (without statistical significance). In conclusion, our study shows a protective effect on CRC of the ACEis limited to males and people under 65years old, which increases in proximal colon in the latter. If confirmed, these results may suggest a novel approach to proximal CRC prevention, given the shortcomings of colonoscopy screening in this location.
- dc.format.mimetype application/pdf
- dc.identifier.citation Dierssen-Sotos T, Gómez-Acebo I, Palazuelos C, Rodriguez-Moranta F, Pérez-Gómez B, Fernández Vazquez JP et al. Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study. Prev Med. 2017 Jun;99:178-84. DOI: 10.1016/j.ypmed.2017.01.011
- dc.identifier.doi http://dx.doi.org/10.1016/j.ypmed.2017.01.011
- dc.identifier.issn 0091-7435
- dc.identifier.uri http://hdl.handle.net/10230/34010
- dc.language.iso eng
- dc.publisher Elsevierca
- dc.relation.ispartof Preventive Medicine. 2017 Jun;99:178-84
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.ypmed.2017.01.011
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Angiotensin converting enzyme inhibitor
- dc.subject.keyword Angiotensin receptor blocker
- dc.subject.keyword Colorectal cancer
- dc.subject.other Còlon -- Càncer
- dc.title Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain studyca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion